Afalase, tablets 100 pcs
€25.67 €23.77
Pharmacodynamics
It was shown experimentally and clinically that antibodies to prostate-specific antigen (PSA) affinity purified modify the functional activity of endogenous PSA, altered in benign prostatic hyperplasia, which is accompanied by strengthening of the regulatory effect of this antigen on functional and metabolic processes in the prostate tissue, have a pronounced anti-inflammatory and anti-edema effect.
Antibodies to endothelial NO-synthase affinity purified promotes an increase in the rate of blood flow, including in the vessels of the penis and prostate, has a protective effect in relation to the endothelium (helps reduce vascular reactivity, decrease
vascular spasm and improve peripheral microcirculation).
The combined use of the components in the complex preparation “Afalase” is accompanied by a synergetic effect: antibodies to endothelial NO-synthase increase antiproliferative and anti-inflammatory activity of antibodies to PSA due to their endothelioprotective effect and improvement of vascularization. The synergistic effect is probably also due to nonspecific
mechanisms of enhancing intracellular signal transduction by dilutions of antibodies to endothelial NO synthase.
In patients with benign prostatic hyperplasia (BPH) the preparation if used for 12 months facilitates the reduction of the prostate volume, improvement of urodynamic parameters (decrease of residual urine volume, increase of maximum urine velocity), significant decrease of dysuric disorders severity without affecting PSA level. The drug improves quality of life of patients with BPH.
Pharmacokinetics
The sensitivity of modern physico-chemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, chromatography-mass spectrometry) does not allow to estimate the content of active substances of the drug Afalase in biological fluids, organs and tissues, which makes it technically impossible to study pharmacokinetics.
Indications
Prostatitis, Erectile dysfunction, Urinary disordersAphalase is indicated for use in adults.
Benign prostatic hyperplasia.
Dysuric disorders (as part of complex therapy): frequent urges to urination, difficulty in urination, pain and discomfort in the perineum.
Active ingredient
Antibodies
Composition
Active ingredients:
Antibodies to endothelial NO-synthase affinity purified – 0.006 g*,
Antibodies to prostate-specific antigen affinity purified – 0.006 g*.
Excipients: lactose monohydrate, microcrystalline cellulose, magnesium stearate.
* Applied on lactose monohydrate as a mixture of three active water-alcohol dilutions of the substance, diluted respectively 10012, 10030, 100200 times.
How to take, the dosage
Inside. It is recommended to take the preparation in the morning and in the evening (keep it in the mouth until dissolving completely – after meals).
In case of dysuric disorders it is recommended to take the preparation during 16 weeks.
It is recommended to take the preparation up to 4 times a day during the first 2-3 weeks of therapy if the pain syndrome and dysuric disturbances are marked.
In order to prevent the growth of the prostate gland in patients with BPH and to reduce the risk of disease progression it is recommended to take the preparation twice a day, in the morning and in the evening during 12 months.
Interaction
Incompatibilities with other drugs have not yet been registered.
Special Instructions
The drug contains lactose monohydrate; therefore, it is not recommended for patients with congenital galactosemia, glucose malabsorption syndrome or congenital lactase deficiency.
Synopsis
The tablets are flat and cylindrical, rimmed and beveled, white to almost white. The flat side with a rib is labeled MATERIA MEDICA, the other flat side is labeled AFALAZA.
Contraindications
Increased individual sensitivity to the drug components.
Age under 18 years.
Lactase deficiency, lactose intolerance, glucose-galactose malabsorption.
Side effects
Possible reactions of individual hypersensitivity to the components of the drug.
.
Overdose
In an accidental overdose, dyspepsia is possible due to the excipients in the drug.
Pregnancy use
The drug Afalaza is not intended for use in women.
Similarities
Proproten-100, Anaferon, Tenoten, Afala, Colophort, Regaline, Impaza, Artrofon, Divase, Tenoten for children, Anaferon for children
Weight | 0.050 kg |
---|---|
Shelf life | 3 years. Do not use after the expiration date. |
Conditions of storage | In the dark place at a temperature not exceeding 25 ° C. Keep out of reach of children. |
Manufacturer | Materiala Medica Holding, Russia |
Medication form | lozenges |
Brand | Materiala Medica Holding |
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