Adepress, 20 mg 30 pcs.
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Adepress is an antidepressant. It is a selective inhibitor of serotonin reuptake (5-hydroxytryptamine, 5-NT) by brain neurons, which determines its antidepressant effect and effectiveness in treatment of obsessive-compulsive (OCD) and panic disorder.
Paroxetine has low affinity for m-cholinoreceptors (has a weak anticholinergic effect), α1-, α2- and β-adrenoreceptors, and dopamine (D2), 5HT1-like, 5HT2-like and histamine H1-receptors.
Paroxetine does not impair psychomotor functions and does not potentiate the inhibitory effects of ethanol.
According to behavioral and EEG studies, paroxetine shows weak activating properties when it is prescribed in doses higher than those needed to inhibit serotonin uptake. In healthy volunteers, it does not cause significant changes in BP, HR and EEG.
Stress, Phobias and Panic Attacks
- Depression of all types, including reactive, severe endogenous depression and depression accompanied by anxiety;
- Obsessive-Compulsive Disorder (OCD);
- Panic Disorder, including fear of being in a crowd (agoraphobia;
- Social Anxiety Disorder/Social Phobia
- Panic disorder including fear of being in a crowd (agoraphobia);
- Social anxiety disorder/social phobia;
- Generalized anxiety disorder;
- Post-traumatic stress disorder.
1 tablet contains paroxetine (in the form of hemihydrate hydrochloride) 20 mg;
calcium hydrophosphate (calcium phosphate displaced),
sodium carboxymethyl starch (primogel),
How to take, the dosage
Tablets Adepress should be taken once a day, in the morning, with a meal, without chewing, with water.
The dose is chosen individually during the first 2-3 weeks after the start of therapy and subsequently adjusted if necessary. The effect in most cases develops gradually. The dose should be increased by 10 mg every week until a therapeutic effect is achieved. The maximum daily dose should not exceed 60 mg/day.
In case of renal and/or hepatic impairment, the recommended dose is 20 mg/day.
In elderly patients, the daily dose should not exceed 40 mg.
In order to prevent relapses, maintenance therapy should be given. After symptoms of depression have disappeared, this course may be 4-6 months, and for obsessive and panic disorder more than 4-6 months.
An abrupt withdrawal of the drug should be avoided. In order to prevent the development of withdrawal syndrome, discontinuation of the drug Adepress should be done gradually.
In order to avoid the development of malignant neuroleptic syndrome, Adepress should be prescribed with caution in patients taking neuroleptics.
Hyponatremia may occur in elderly patients while taking Adepress.
In some cases, adjustment of the dose of concomitant insulin and/or oral hypoglycemic drugs is required.
If seizures develop, treatment with Adepress is discontinued.
The drug should be discontinued at the first signs of mania.
In the first few weeks of Adepressor therapy, the patient’s condition should be closely monitored because of possible suicide attempts.
Alcohol should be refrained from taking alcohol during Adepressor therapy due to its increased toxic effects.
Impact on driving and operating machinery
Although paroxetine does not impair cognitive and psychomotor functions, patients should refrain or exercise extreme caution when driving or engaging in other potentially hazardous activities that require increased concentration and rapid psychomotor reactions.
- Simultaneous use of MAO inhibitors and 14 days after their withdrawal;
- Unstable epilepsy;
- .Pregnancy and lactation (breastfeeding) period;
- Children’s age;
- High sensitivity to the components of the drug.
With caution: In hepatic failure, renal failure, closed-angle glaucoma, prostatic hyperplasia, mania, cardiac pathology, epilepsy, seizure states, concurrent administration of electric pulse therapy, concurrent administration of drugs that increase the risk of bleeding, presence of risk factors for increased bleeding and diseases that increase the risk of bleeding, and elderly patients.
CNS and peripheral nervous system: often – somnolence or insomnia, tremor, asthenia, dizziness, anxiety; sometimes – confusion, hallucinations, extrapyramidal disorders, paresthesias, reduced ability to concentrate; rarely – seizures, mania; very rarely – serotonin syndrome (agitation, hyperreflexia, diarrhea), panic disorders.
Sensory organs: in some cases – visual impairment, mydriasis.
Muscular system disorders: myasthenia, myoclonus, arthralgia, myalgia are rare.
The urinary system: frequent urination, rarely – urinary retention.
As to the sexual system: disorders of ejaculation, libido disorders; rarely – hyperprolactinemia/galactorrhea, anorgasmia.
Digestive system disorders: decreased appetite, nausea, vomiting, dry mouth; sometimes – constipation or diarrhea; in some cases – hepatitis.
Cardiovascular system: orthostatic hypotension.
Allergic reactions: rarely – rash, urticaria, ecchymatosis, pruritus, angioedema.
Others: increased sweating; in single cases – hyponatremia, disruption of antidiuretic hormone secretion.
Adepress is not recommended for pregnant women and nursing mothers.
|Conditions of storage|
In a dry, light-protected place at a temperature not exceeding 25 °C
Veropharm AO, Russia
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