Aciclovir-Acrihin, 5% ointment 5 g

Pharmacodynamics

Antiviral drug – synthetic analog of thymidine nucleoside.In infected cells containing viral thymidine kinase, phosphorylation and conversion to acyclovir monophosphate occurs. Under the influence of guanylate cyclase acyclovir monophosphate is converted into diphosphate and under the influence of several cellular enzymes into triphosphate.

High selectivity and low toxicity for humans is conditioned by the absence of required enzyme for acyclovir triphosphate formation in intact cells of macroorganism.

Acyclovir triphosphate “integrates” into DNA synthesized by virus and blocks virus multiplication. Specificity and very high selectivity of action are also due to its predominant accumulation in cells affected by the herpes virus. It is highly active against Herpes simplex virus types 1 and 2; Varicella zoster virus and shingles virus; Epstein-Barr virus. Moderately active against cytomegaloviruses.

Pharmacokinetics

When used on intact skin: absorption is minimal; not detected in blood and urine. On affected skin:absorption is moderate; in patients with normal renal function the serum concentration is up to 0.28 µg/ml, in patients with chronic renal failure (CRF) up to 0.78 µg/ml. Excreted by the kidneys (up to 9.4% of the daily dose).

Indications

– Skin infections caused by Herpes simplex virus types 1 and 2,

– genital herpes,

– shingles,

– varicella.

Active ingredient

Composition

active substance:

acyclovir in terms of 100% substance – 5 g;

auxiliary substances:

Propylene glycol – 40 g,

Vaseline – 12.5 g,

Vaseline oil – 7.5 g,

emulsion wax – 5 g,

macrogol (polyethylene oxide 1500)-1 g,

purified water up to 100 g.

How to take, the dosage

The product is applied with clean hands or with a cotton swab 5 times a day (every 4 hours) in a thin layer on the affected and adjacent skin areas.

Interaction

Special Instructions

Contraindications

With caution – pregnancy, lactation, dehydration, renal failure.

Side effects

Overdose

Symptoms (if accidentally swallowed):

– headache,

– neurological disturbances,

– shortness of breath,

– nausea,

– vomiting,

– diarrhea,

– impaired renal function,

– lethargy,

– convulsions,

– coma.

Treatment:

– maintenance of vital functions,

– hemodialysis.

Pregnancy use

The use of the drug is indicated only when the expected benefit to the mother exceeds the potential risk to the fetus.

The cessation of breastfeeding should be considered during treatment.

Similarities