Aciclovir-Acrihin, tablets 400 mg 20 pcs

The antiviral drug is a synthetic analog of thymidine nucleoside.

In infected cells containing viral thymidine kinase is phosphorylated and converted into acyclovir monophosphate. Under the influence of guanylate cyclase acyclovir monophosphate is converted to diphosphate and to triphosphate under the influence of several cellular enzymes. High selectivity and low toxicity for humans is conditioned by absence of necessary enzyme for acyclovir triphosphate formation in intact cells of macroorganism.

Aciclovir triphosphate “embedding” into DNA synthesized by the virus blocks virus multiplication. Specificity and very high selectivity of action are also due to its preferential accumulation in cells affected by the herpes virus. It is highly active against Herpes simplex viruses of types 1 and 2; Varicella zoster viruses; Epstein-Barr viruses (types of viruses are listed in ascending order of MAC value of acyclovir).

It is moderately active against CMV. In herpes it prevents formation of new rash elements, reduces the probability of cutaneous dissemination and visceral complications, accelerates crusts formation, reduces pain in the acute phase of herpes zoster. It has an immunostimulatory effect.

Indications

Herpes, Skin itching, Colds – Treatment of primary and relapsing severe genital herpes (including in patients with immune disorders) – orally and parenterally;

– Prevention of frequently relapsing (6 or more cases per year) genital herpes (including in patients with immune disorders) – oral.

– treatment of primary and recurrent herpes with skin and mucous membranes lesions caused by Herpes simplex virus type 1 and 2, in patients with immune impairment – orally, parenterally;

– prevention of herpes simplex in patients with immune impairment (including after transplantation and after taking immune medications) – oral. After transplantation and receiving immunosuppressive drugs, HIV-infected patients against chemotherapy) – inside;

– encephalitis caused by Herpes simplex virus type 1 and 2 – parenterally;

– treatment of herpes zoster, caused by Varicella zoster virus in adults – inside; In immunocompromised patients and in generalized herpes zoster in patients with intact immunity – parenterally;

– prevention of herpes zoster caused by Varicella zoster virus, after the initial period of acyclovir for parenteral use in all immunocompromised patients (incl.ч. After transplantation and while taking immunosuppressive drugs, HIV-infected patients, against the background of chemotherapy) – orally;

– herpes zoster with eye lesions – orally, parenterally;

– Generalized infection in infants caused by Herpes simplex virus – parenterally;

– Varicella in patients with intact immunity within 24 hours after the appearance of the typical rash – internally, in patients with compromised immunity – parenterally.

Active ingredient

Acyclovir

Composition

1 tablet:

– acyclovir 400 mg.

Supplementary substances:

microcrystalline cellulose,

polyvinylpyrrolidone,

indigo carmine,

magnesium stearate,

sodium starch glycolate,

purified water.

How to take, the dosage

Overly, during or immediately after a meal, with plenty of water.

Dosing regimen is set individually depending on the severity of the disease.

Infections of skin and mucous membranes caused by Herpes simplex virus types 1 and 2

Adults. – 200 mg 5 times a day (every 4 hours while awake, except for nighttime sleep) for 5 days, for the treatment of genital herpes – 10 days, if necessary, the treatment period may be extended.

As part of complex therapy in cases of severe immunodeficiency, including advanced clinical manifestations of HIV infection (including early clinical manifestations of HIV infection and AIDS stage), after bone marrow implantation – 400 mg five times a day.

For prevention of recurrent infections caused by Herpes simplex virus types 1 and 2 in patients with normal immune status
Adults – 200 mg 4 times a day every 6 hours, duration of course from b to 12 months.

For the prevention of infections caused by Herpes simplex virus types 1 and 2 in immunodeficient patients
For the prevention of infections caused byHerpes simplex virus types 1 and 2 in immunodeficient patients

Adults – 200 mg 4 times a day every 6 hours, the maximum dose is up to 400 mg 5 times a day depending on the severity of infection.

When treating shingles – 800 mg 5 times daily (every 4 hours while awake, except for nighttime sleep) for 7-10 days.

Children over 3 years are prescribed the drug in the same dose as adults.

Treatment of chicken pox: Adults and children over 6 years old – 800 mg 4 times daily; children 3-6 years old – 400 mg 4 times daily. More precisely the dose can be determined at the rate of 20 mg/kg.
The course of treatment is 5 days.

In patients with impaired renal function the dosage and dosing regime should be adjusted depending on the creatinine clearance value and the type of infection. For treatment of infection caused by Herpes simplex with creatinine clearance less than 10 ml/min the daily dose should be reduced up to 400 mg divided into 2 intakes (with intervals not less than 12 hours between them, i.e. 200 mg 2 times per day).

In the treatment of infections caused by Varicella zoster and maintenance therapy in patients with severe immunodeficiency – In patients with creatinine clearance 10-25 ml/min the preparation is administered by 800 mg 3 times daily with 8 hours interval, and in patients with creatinine clearance less than 10 ml/min – by 800 mg 2 times daily with 12 hours interval.