Aceclofenac, 100 mg 20 pcs
€6.38 €5.32
Aceclofenac is a non-steroidal anti-inflammatory agent derived from phenylacetic acid. Aceclofenac has analgesic, anti-inflammatory, antipyretic effects, which are associated with inhibition of cyclooxygenase 1 and 2, which regulate prostaglandin production.
Indications
The drug is prescribed:
as part of complex treatment of inflammatory diseases of the musculoskeletal system (osteoarthrosis, rheumatoid, psoriatic and juvenile arthritis, arthritis, ankylosing spondylitis or spondylitis);
for the relief of pain and inflammation in rheumatism, toothache, and glenohumeral periarthritis.
The use of Aceclofenac is not able to completely cure these diseases, but quickly reduces inflammation and pain.
Pharmacological effect
Aceclofenac is a non-steroidal anti-inflammatory drug derived from phenylacetic acid. Aceclofenac has analgesic, anti-inflammatory, antipyretic effects, which are associated with inhibition of cyclooxygenase 1 and 2, which regulate the production of prostaglandins.
Special instructions
As a precautionary measure, it is recommended to use the minimum effective and active dosage during treatment with the drug. Periodic monitoring of the liver and kidneys, peripheral blood picture, stool condition (lack of blood), and the functioning of the cardiovascular system are also indicated.
During treatment, you should not drive a car or perform potentially hazardous activities.
The risk of allergies or skin reactions is higher in the first months of taking the medicine. If damage to the oral mucosa, skin rashes, or other signs of allergy occur, therapy must be interrupted.
The process of platelet inhibition during treatment with the drug is reversible, the blood composition is normalized some time after discontinuation of the drug.
Active ingredient
Aceclofenac
Composition
Active substances:
Contraindications
The medicine is contraindicated:
if you are allergic to the active substance;
patients with ulcers and erosions in the gastrointestinal tract, during an exacerbation;
for Crohn’s disease and ulcerative colitis;
if there is a suspicion of bleeding from the gastrointestinal tract;
for severe liver diseases and liver failure;
pregnant women;
patients with disorders of hematopoiesis or bleeding disorders;
during breastfeeding;
with renal failure, hyperkalemia, progressive kidney diseases;
children under 18 years of age;
during the recovery period after coronary artery bypass surgery;
with the “aspirin triad”;
persons suffering from severe heart failure.
Caution should be observed:
for diseases of the kidneys, gastrointestinal tract and liver of moderate and mild severity;
if the patient has Helicobacter bacteria in the gastrointestinal tract;
for bronchial asthma;
persons with low blood pressure;
after major operations, if the volume of circulating blood is reduced;
with ischemia;
elderly people;
patients with cerebrovascular diseases;
for diabetes mellitus;
after long-term treatment with NSAIDs;
alcoholics and smokers;
for severe somatic diseases;
patients with hemostasis defects;
with systemic lupus erythematosus;
in combination with anticoagulants, serotonin reuptake inhibitors, antiplatelet agents.
Ointment or cream should not be applied to damaged skin.
Side Effects
During treatment with Aceclofenac the following are often observed:
dizziness, nausea, abnormalities in the gastrointestinal tract, abdominal pain, indigestion, diarrhea;
increased activity of liver enzymes, allergic reactions in the form of skin rashes and itching.
Less commonly developed:
anemia, anaphylactic reactions, decreased visual acuity;
increased blood pressure, heart failure, shortness of breath;
increase in the concentration of creatinine and urea in the blood;
constipation, mouth ulcers, increased gas formation, gastritis, vomiting;
stomach ulcer, melena, hemorrhoids;
dermatitis, itching, Quincke’s edema, urticaria.
Very rarely occur:
muscle spasms, weakness and feeling of fatigue, weight gain, hyperkalemia, eczema;
renal failure, nephrotic syndrome, nephritis;
purpura, Stevens-Johnson syndrome, soft tissue infections due to chickenpox, toxic epidermal necrolysis;
granulocytopenia, neutropenia, disruption of hematopoietic processes, thrombocytopenia, hemolytic anemia;
depression, vivid dreams and nightmares, sleep disturbances, vertigo, vasculitis;
tremor, perversion of taste, drowsiness, paresthesia, tinnitus;
intestinal perforation, pancreatitis, ulcerative colitis, vomiting with blood;
hyperemia of the skin, hot flashes, tachycardia;
bronchospasm, stomatitis, hepatitis.
Interaction
Anticoagulants when combined with tablets increase the risk of bleeding. During treatment, it is recommended to periodically monitor blood clotting parameters.
Aceclofenac tablets increase the plasma concentration of digoxin, phenytoin, and lithium-based drugs.
The substance, when combined with antihypertensive drugs and diuretics, reduces the effectiveness of the latter.
The combination of the drug with potassium-sparing diuretics increases the likelihood of developing hyperkalemia.
Caution should be used when combining the drug with NSAIDs and glucocorticosteroids, as the drug increases the toxicity of methotrexate and cyclosporine.
Aspirin reduces the plasma concentration of Aceclofenac.
The combination of the drug with hypoglycemic drugs requires constant monitoring of blood glucose levels.
Overdose
There have been no reported cases of drug overdose in humans.
Symptoms of overdose are: headaches, cramps, vomiting, abdominal pain, nausea, dizziness. Enterosorbents are used as therapy, the stomach is washed, and symptomatic treatment is performed. The drug does not have a specific antidote; hemodialysis and forced diuresis are ineffective.
Storage conditions
Store the tablets in a cool, dark place, away from children.
Shelf life
3 years.
Manufacturer
Berezovsky Pharmaceutical Plant, Russia
Shelf life | 3 years. |
---|---|
Conditions of storage | Tablets are stored in a cool, dark place, away from children. |
Manufacturer | Berezovsky Pharmaceutical Plant, Russia |
Medication form | pills |
Brand | Berezovsky Pharmaceutical Plant |
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