🐾 Vetmedin solution 0.75 mg/ml vial, 5 ml

Pimobendan is a benzimidazole-pyridazinone derivative and has positive inotropic and vasodilatory (vasodilator) effects. Unlike cardiac glycosides positive inotropic effect of pimobendan is caused by two mechanisms: increase of cardiac muscle fibers sensitivity to calcium and inhibition of phosphodiesterase III (vasodilating effect).
Due to positive inotropic and vasodilatory effects in heart failure the drug increases strength of heart contractions and decreases both preload and postload.
During intravenous administration of the drug the bioavailability of pimobendanum is 100%. After intravenous administration its distribution volume is 2.6 L/kg, indicating that pimobendan is rapidly distributed in tissues. Binding to plasma proteins is 93%.
The half-life of pimobendan in blood plasma is 0.4±0.1 hours, and the elimination half-life of its active metabolite is 2.0±0.3 hours. Almost all amount of pimobendan is eliminated from animals via feces.
Vetmedin by degree of exposure on the body is classified as a low-hazard substance (4 class of hazard according to GOST 12.1.007-76), it has no sensitizing, embryotoxic, teratogenic and mutagenic properties.

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