🐾 Domitor solution 0.1%, vial 10 ml

The active substance of the dominator is medetomidine. Medetomidine-a2-agonist whose main effect is inhibition of nerve impulse transmission in adrenergic synapses due to competition with noradrenaline. Under the action of the drug in animals there is CNS depression and increase of pain threshold.
The action of medetomidine depends on the dose: small doses have medium sedative effect without analgesia, while large doses cause significant sedative effect and analgesia. Medetomidine is quickly absorbed after intramuscular injection, the drug concentration in blood reaches a maximum in 15-30 minutes.
Medetomidine is rapidly distributed in the body. From 85% to 90% of the drug is bound to serum proteins. Medetomidine is oxidized in the liver, a small part is methylated in the kidneys. Most of the drug metabolites are excreted with the urine. The elimination half-life is 1-2 hours.

Indications

For local anesthesia, therapeutic blockades in various diseases, dissolving penicillin and other drugs. For treatment of various non-contagious diseases in combination with specific and symptomatic agents the drug is prescribed for stomach ulcers, atony with tympany of pre-stomach and intestines, dyspepsia, spastic colic, mechanical bowel obstruction, traumatic peritonitis, reticuloperitonitis, spasm of blood vessels (blockade by V.V. Mosin and lumbar blockade by A.I. Fedotov). In ophthalmology novocaine is used for keratitis, keratoconjunctivitis, periodic eye inflammation in horses (suborbital blockade). In surgery Novocaine is used to treat wounds, ulcers, fistulas, myositis, papillomatosis (intradermal or intravenous). Novocaine is used in obstetrics and gynecology practice for metritis, endometritis, uterine and vaginal prolapse, retention of placenta in cows and goats (paranephral blockade), serous-catarrhal mastitis (central injection in the affected lobe and by udder blockade according to B.A. Bashkirov or D.D. Logvinov).

Active ingredient

Medetomidine

Composition

Aqueous solution for injection, containing 1 ml as an active ingredient 1 mg of medetomidine hydrochloride.

How to take, the dosage

Domitor in pure form is administered intramuscularly, intravenously and subcutaneously to dogs, intramuscularly and subcutaneously to cats. Maximum effect occurs after 10-15 min. Duration of clinical action depends on the dose and varies considerably (30 to 80 min). The drug acts faster after intravenous administration, slower after intramuscular and subcutaneous administration. The degree of sedation may be adjusted by adjusting the drug dose.
In order to maintain the sedative and analgesic effect the drug may be administered repeatedly 10-15 minutes after the first injection.
In order to achieve sedative and analgesic effect the drug is administered in the following doses:
dogs: 0.1-0.8 ml/10 kg,
cats: 0.05-0.15 ml/kg.
The drug doses vary depending on the desired effect, individual features and breed of the animal. High doses cause pronounced sedative effect and analgesia, low doses have only sedative effect.
Small breed dogs require a higher dose of Dominator than large dogs. Domitor administration may cause decreased heart rate and respiratory movements.

Contraindications

Contraindications to use are: heart failure; liver or kidney function disorders; pregnancy.

Side effects

Blood pressure rises immediately after injection, then falls to normal or remains slightly reduced. Some dogs and most cats may vomit 5-10 minutes after the injection, and in some cats it is observed even on exit from anesthesia. In some cases there is a slight twitching of individual muscle groups. Under the effect of the drug the heart rate slows down and body temperature decreases. After drug administration animals shall be kept warm for at least 12 hours.
In case of circulatory and respiratory oppression oxygenation shall be indicated. Atropine may be used to increase heart rate, but it should be taken into account that it may cause arrhythmia. The action of the domitor can be eliminated by using a specific antagonist – antisedan.