Zyprexa, 10 mg 28 pcs

Zyprexa is an antipsychotic.

As a ligand of serotonin (2A/2C, 3, 6), dopamine (D₁-D₅), m-choline (m₁-m₅), histamine H₁– and alpha₁-adrenoreceptors, and selectively affects the limbic system.

Pharmacokinetics

It is well absorbed, C_max in plasma in 5-8 h. Metabolized in the liver (by conjugation and oxidative pathways) to inactive metabolites. The main metabolite – 10-N-glucuronide – does not pass through the BBB. Mean T_1/2 varies (depending on age and sex) between 21-54 h.

Indications

An acute form of schizophrenia and other psychoses, accompanied by pronounced positive (delusions, hallucinations, thought disorders, hostility, suspicion) and/or negative (blunted affect, emotional and social isolation, poor speech activity) symptoms.

Secondary affective symptoms due to schizophrenia and related disorders.

Pharmacological effect

Zyprexa is an antipsychotic.

Being a ligand of serotonin (2A/2C, 3, 6), dopamine (D1-D5), m-cholino- (m1-m5), histamine H1- and alpha1-adrenergic receptors, it selectively affects the limbic system.

Pharmacokinetics

Well absorbed, Cmax in plasma is after 5–8 hours. Metabolized in the liver (via conjugation and oxidative pathways) to inactive metabolites. The main metabolite, 10-N-glucuronide, does not cross the BBB. The average T1/2 varies (depending on age and gender) within 21–54 hours.

Active ingredient

Olanzapine

Composition

Active ingredient:

olanzapine 10 mg

Pregnancy

Zyprexa is contraindicated during pregnancy, breastfeeding and children under 18 years of age.

Contraindications

Hypersensitivity

Side Effects

Frequent – drowsiness, weight gain;

rare – dizziness, dry mouth, constipation, peripheral edema, orthostatic hypotension, akathisia, dystonia, eosinophilia (asymptomatic), slight and temporary increase in prolactin levels (gynecomastia, lactorrhea), liver transaminase activity.

Interaction

Weakens the effects of levodopa and dopamine agonists.

Activated carbon reduces bioavailability by 50–60% when taken orally.

Smoking and carbamazepine speed up metabolism.

There was no obvious interaction with antacids, cimetidine, imipramine, warfarin, diazepam, lithium, theophylline, biperiden.

Overdose

Symptoms: nausea, confused speech, drowsiness.

Mydriasis, respiratory depression, hypotension, and extrapyramidal disorders were noted in animal experiments.

Treatment: there is no specific antidote.

Treatment is symptomatic, with the mandatory use of activated carbon, ensuring good ventilation and oxygen saturation;

in case of collapse – intravenous administration of norepinephrine (but not adrenomimetics with beta-stimulating activity – adrenaline, dopamine, etc.).

Storage conditions

In a dry place, protected from light, at a temperature of 15–30 °C

Shelf life

3 years

Manufacturer

Lilly del Caribe Inc., Puerto Rico