Zorex, 250 mg+10 mg capsules, 2 pcs

Zorex is a complexing drug. Donator of sulfhydryl (thiol) groups. It has a detoxifying effect (including in relation to products of ethanol half-life, heavy metals and their compounds, arsenic compounds). Studies have shown hepatoprotective and antioxidant effect of unitiol.

The active sulfhydryl groups of unitiol, interacting with thiol poisons and products of alcohol (ethanol) half-life found in blood and tissues, form non-toxic compounds (complexes) with them which are excreted with urine.

When administered orally, unitiol penetrates the bloodstream into the liver, where it quickly and physiologically irreversibly binds to acetaldehyde, which causes the subsequent elimination of ethanol from other organs and tissues. Zorex also activates alcohol dehydrogenase, increasing the process of ethanol oxidation and detoxification of its toxic agents by the liver enzyme system.

The presence of calcium pantothenate in the preparation Zorex enhances the detoxifying effect of unitiol. Calcium pantothenate is well absorbed from intestine and is broken down to release pantothenic acid which participates in carbohydrate and fat metabolism, stimulates formation of corticosteroids and accelerates regeneration processes.

Pharmacokinetics

Intake

After taking a capsule containing 250 mg of unitiol the Cmax of unitiol in blood is reached after 1.5 hours and is 90-140 mg/l. Average retention time of the preparation in the body is 9-11 hours (10.16±0.39 h), including in GIT – 15-20 min.

Calcium pantothenate is well absorbed from the intestine and is broken down, releasing pantothenic acid.

The T1/2 is 7.5±0.46 h.

About 60% of the drug is excreted in the urine, partially in the feces.

Indications

Composition

Active ingredients:

dimercaptopropane sulfonate sodium monohydrate (unitiol) 250 mg;

Calcium pantothenate 10 mg;

Associates:

MCC;

Citric acid monohydrate;

Pregelatinized starch;

magnesium hydrophosphate trihydrate;

povidone;

colloidal silicon dioxide (aerosil)

How to take, the dosage

The drug is prescribed orally. Capsules should be taken 30 minutes before a meal, without chewing, with water.

For the prevention of a hangover, 1 capsule (250 mg + 10 mg) in the evening before going to bed.

For the treatment of alcohol withdrawal syndrome – 1 capsule (250 mg + 10 mg) 1-2 times a day (the doses are recalculated to unitiol and calcium pantothenate). If necessary, daily dose can be increased to 750 mg (for unitiol), and the frequency of intake should be increased to 3 times a day. The drug should be taken for 3-7 days until the symptoms of intoxication stop.

In chronic alcoholism, 1 capful (150 mg + 7 mg) 1-2 times a day for 10 days (the doses are recalculated to unitiol and calcium pantothenate).

In case of poisoning by arsenic compounds and heavy metal salts 300-1000 mg/day (by unitiol) are prescribed, divided into 2-3 doses for 7-10 days.

Interaction

It is not compatible with medicines containing salts of heavy metals, as well as with alkalis (quickly decomposes).

Special Instructions

Impact on the ability to drive and operate machinery

The drug does not affect the performance of potentially hazardous activities requiring particular attention and quick reactions (driving a car and other vehicles, working with moving mechanisms, work of dispatcher and operator, etc.).

Contraindications

With caution, the drug should be used in patients with low blood pressure.

Side effects

Allergic reactions: rare – skin itching, urticaria, skin and mucosa rash, mucosa edema, genital itching, stomatitis; very rare – appearance of an allergic reaction of the type of angioedema or Stephen-Johnson syndrome (sudden body temperature increase, malaise, spotty-vesicular or bullous rash on the skin, mucosa of the mouth, genitals, in the anus).

In this case, the drug should be stopped and a doctor should be seen.

The risk of allergic reactions is greater in people with bronchial asthma or a history of allergies.

When used in high doses: nausea, dizziness, tachycardia, pale skin.

Overdose

Symptoms:

pant shortness of breath, hyperkinesias, lethargy, lethargy, stunned, transient seizures.

Treatment:

Gastric lavage, prescription of activated charcoal, laxatives. Symptomatic therapy is carried out, in acute cases oxygen therapy is indicated, administration of dextrose.

Pregnancy use

There are no data on the use of Zorex during pregnancy and lactation (breast-feeding).

In the absence of the necessary information the use is contraindicated in pregnancy and during lactation (breast-feeding).