Zalain, vaginal suppositories 300 mg

Pharmacotherapeutic group:

antifungal agent

ATX code: G01AF

Pharmacological properties

Sertaconazole is an antifungal agent derived from imidazole and benzothiophene. It has fungistatic and fungicidal effect in therapeutic doses. It is active against fungi of the genus Candida. The mechanism of action of sertaconazole is inhibition of ergosterol synthesis and increase in cell membrane permeability, which leads to lysis of the fungus cell. It also has antibacterial activity against Gram-positive bacteria (Staphylococcus and Streptococcus).

Pharmacokinetics

There is no systemic absorption after intravaginal administration. Unchanged sertaconazole is not detected in either plasma or urine.

Indications

Local treatment of infections of the vaginal mucosa caused by fungi of the genus Candida (vulvovaginal candidiasis).

Pharmacological effect

Pharmacotherapeutic group: antifungal agent

ATX code: G01AF

PHARMACOLOGICAL PROPERTIES

Sertaconazole is an antifungal agent, a derivative of imidazole and benzothiophene. It has fungistatic and fungicidal effects in therapeutic doses. Active against fungi of the genus Candida. The mechanism of action of sertaconazole is to inhibit the synthesis of ergosterol and increase the permeability of the cell membrane, which leads to lysis of the fungal cell. It also has antibacterial activity against gram-positive bacteria (staphylo- and streptococci).

PHARMACOKINETICS

There is no systemic absorption after intravaginal use. Unchanged sertaconazole is not detected either in blood plasma or in urine.

Active ingredient

Sertaconazole

Composition

Active substance:

sertaconazole nitrate 300 mg,

excipients:

vitepsol,

suppotir,

anhydrous colloidal silicon dioxide.

Pregnancy

There are no sufficient data on the use of sertaconazole during pregnancy and lactation.

However, taking into account the method of administration of the drug (single administration), as well as the lack of systemic absorption of the drug after intravaginal administration, the use of sertaconazole during pregnancy and lactation is possible if the potential benefit to the mother outweighs the possible risk to the fetus or child.

Contraindications

Hypersensitivity to imidazole derivatives, benzothiophene and other components of the drug.

Side Effects

Rarely: burning sensation, itching in the vagina, which disappear on their own during treatment and do not require discontinuation of the drug.

These side effects are classic for topical medications and reflect the effectiveness of the drug.

Allergic reactions are possible.

Interaction

Simultaneous use of the drug with local contraceptives may lead to a weakening of the spermicidal effect of the latter.

Storage conditions

At a temperature not exceeding 30 °C.

Shelf life

3 years

Manufacturer

EGIS, Hungary