Zalain, 2% cream 20 g

ATC code: D01AС14

Pharmacological properties

Sertaconazole is an imidazole derivative for topical use with a broad spectrum of action against pathogenic fungi (Candida albicans, C. Tropicalis, C. spp, Pityrosporum orbiculare), dermatophytes (Trichophyton, Epidermophyton and Microsporum) and pathogens of skin and mucous membrane infections (gram-positive strains of staphylococci and streptococci).

The mechanism of action of sertaconazole is inhibition of ergosterol synthesis, the main sterol of fungal and yeast membranes, and increase of cell membrane permeability, which leads to lysis of the fungus cell.

Pharmacokinetics

Sertaconazole nitrate is undetectable in blood and urine when used topically.

Indications

Local treatment of superficial skin mycoses: ringworm, Tinea pedis (athlete’s foot), Tinea crusis, Tinea corporis, Tinea barbae (beard mycosis), Tinea manus, candidiasis (Monolisiasis), as well as Pityiriasis versicolor (Pityrosporum orbiculare).

Pharmacological effect

ATX code: D01AC14

PHARMACOLOGICAL PROPERTIES

Sertaconazole is an imidazole derivative for topical use with a broad spectrum of action against pathogenic fungi (Candida albicans, C. Tropicalis, C. Spp., Pityrosporum orbiculare), dermatophytes (Trichophyton, Epidermophyton and Microsporum) and pathogens of infections of the skin and mucous membranes (Gram-positive strains of staphylococci and streptococci).

The mechanism of action of sertaconazole is to inhibit the synthesis of ergosterol, the main sterol of fungal and yeast membranes, and increase the permeability of the cell membrane, which leads to lysis of the fungal cell.

Pharmacokinetics

When applied topically, sertaconazole nitrate is not detectable in the blood and urine.

Active ingredient

Sertaconazole

Composition

1 g of cream contains 20 mg of the active ingredient – sertaconazole nitrate, as well as excipients:

ethylene glycol and polyethylene glycol palmitostearate,

polyglycolized saturated glycerides,

glycerol isostearate,

paraffin oil,

methyl p-hydroxybenzoate,

sorbic acid,

purified water.

Contraindications

Hypersensitivity to antifungal agents (imidazole derivatives) or excipients of the cream.

Side Effects

Contact dermatitis.

Rapidly passing local erythematous reactions are possible, which does not require discontinuation of the drug.

Storage conditions

At temperatures below 25 °C

Shelf life

3 years

Manufacturer

EGIS, Hungary