Xymelin Extra, 84 mcg+70 mcg/dose 10 ml

Combination drug for topical use in ENT practice.

Xylometazoline is an alpha-adrenomimetic. Causes narrowing of the blood vessels of the nasal mucosa, thus eliminating edema and hyperemia of the nasopharyngeal mucosa. It relieves nasal breathing in rhinitis.

Ipratropium bromide has an anticholinergic effect. When administered intranasally it reduces nasal mucosal gland secretion.

In therapeutic doses Ximeline Extra does not irritate the mucosa and does not cause hyperemia. The action of the drug starts within 5-10 minutes and lasts for 6-8 hours.

Pharmacokinetics

In intranasal administration, xylometazoline hydrochloride and ipratropium bromide are both little absorbed and present in the blood plasma in negligible amounts.

Indications

Xymelin Extra is used for acute respiratory diseases with rhinitis, acute allergic rhinitis, hay fever, sinusitis (to reduce swelling of the mucous membrane).

Pharmacological effect

Combined preparation for local use in ENT practice.

Xylometazoline is an alpha-adrenergic agonist. Causes a narrowing of the blood vessels of the nasal mucosa, thus eliminating swelling and hyperemia of the nasopharyngeal mucosa. Facilitates nasal breathing during rhinitis.

Ipratropium bromide has an anticholinergic effect. When administered intranasally, it reduces the secretion of the glands of the nasal mucosa.

In therapeutic doses, Xymelin Extra does not irritate the mucous membranes and does not cause hyperemia. The effect of the drug occurs within 5-10 minutes and lasts for 6-8 hours.

Pharmacokinetics

When administered intranasally, xylometazoline hydrochloride and ipratropium bromide are poorly absorbed and are present in the blood plasma in small quantities.

Special instructions

Should not be used for a long time, for example for chronic rhinitis.

Active ingredient

Ipratropium bromide, Xylometazoline

Composition

1 ml nasal spray contains:

Active ingredients:

Ipratropium bromide monohydrate 0.6 mg,

Xylometazoline hydrochloride 0.5 mg;

Excipients:

Disodium edetate dihydrate,

glycerol (85%),

concentrated hydrochloric acid (up to pH 4.5),

sodium hydroxide (up to pH 4.5),

purified water.

Pregnancy

During pregnancy and lactation, the drug should be used only after a thorough assessment of the risk-benefit ratio for the mother and fetus; recommended doses should not be exceeded.

The aerosol is not prescribed to children under 3 years of age. Nasal drops 0.1% for children under 2 years of age are prescribed only by a doctor.

Contraindications

Individual hypersensitivity to the components of the drug, hypertension, tachycardia, severe atherosclerosis, glaucoma, atrophic rhinitis, thyrotoxicosis, history of surgical interventions on the meninges, age under 18 years.

Side Effects

Local reactions: with frequent and/or prolonged use – irritation and/or dryness of the nasopharyngeal mucosa, burning, tingling, sneezing, hypersecretion; rarely – swelling of the nasal mucosa.

Systemic reactions: rarely – palpitations, tachycardia, arrhythmias, increased blood pressure, headache, vomiting, insomnia, blurred vision; with long-term use in high doses – depression.

Interaction

Incompatible with MAO inhibitors and tricyclic antidepressants.

Overdose

Symptoms: increased side effects.

Treatment: symptomatic therapy.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

3 years

Manufacturer

Takeda GmbH, Germany