Xymelin Extra, 84 mcg+70 mcg/dose 10 ml

Combination drug for topical use in ENT practice.

Xylometazoline is an alpha-adrenomimetic. Causes narrowing of the blood vessels of the nasal mucosa, thus eliminating edema and hyperemia of the nasopharyngeal mucosa. It relieves nasal breathing in rhinitis.

Ipratropium bromide has an anticholinergic effect. When administered intranasally it reduces nasal mucosal gland secretion.

In therapeutic doses Ximeline Extra does not irritate the mucosa and does not cause hyperemia. The action of the drug starts within 5-10 minutes and lasts for 6-8 hours.

Pharmacokinetics

In intranasal administration, xylometazoline hydrochloride and ipratropium bromide are both little absorbed and present in the blood plasma in negligible amounts.

Indications

Xymelin Extra is used in acute respiratory diseases with rhinitis, acute allergic rhinitis, pollinosis, sinusitis (in order to reduce mucosal edema).

Active ingredient

Composition

1 ml of nasal spray contains:

The active ingredients:

Ipratropium bromide monohydrate 0.6 mg,

Xylometazoline hydrochloride 0.5 mg;

Associates:

Dinatrium edetate dihydrate,

Glycerol (85%),

Concentrated hydrochloric acid (up to pH 4.5),

sodium hydroxide (up to pH 4.5),

purified water.

How to take, the dosage

Intranasally.

In adults over 18 years of age: 1 injection in each nasal passage 3 times a day.

The drug is used for at least 10 days without medical advice.

One injection of Xymelin Extra contains about 70 micrograms of xylometazoline hydrochloride and 84 micrograms of ipratropium bromide.

Interaction

Incompatible with MAO inhibitors and tricyclic antidepressants.

Special Instructions

Should not be used for long periods of time, such as with chronic rhinitis.

Contraindications

Individual hypersensitivity to the drug components, AH, tachycardia, marked atherosclerosis, glaucoma, atrophic rhinitis, thyrotoxicosis, surgical interventions on the brain sheath in the anamnesis, age under 18 years.

Side effects

Local reactions: with frequent and/or prolonged use – irritation and/or dryness of the nasopharyngeal mucosa, burning, tingling, sneezing, hypersecretion; rarely – swelling of the nasal mucosa.

Systemic reactions: rarely – palpitations, tachycardia, arrhythmias, increased BP, headache, vomiting, insomnia, visual disturbances; with prolonged use in high doses – depression.

Overdose

Symptoms: worsening of side effects.

Treatment: conducting symptomatic therapy.

Pregnancy use

During pregnancy and lactation the drug should be used only after careful assessment of the risk-benefit ratio for the mother and fetus; the recommended doses should not be exceeded.

The aerosol is not prescribed for children under 3 years of age. Nasal drops 0.1% for children under 2 years old are prescribed only by a doctor.