Xymelin Eco, spray 35 mcg/dose 10 ml

Pharmacological properties

Csimelin refers to a group of local vasoconstrictors (decongestants) with alpha-adrenomimetic action, causes narrowing of the blood vessels of the nasal mucosa, thus eliminating edema and hyperemia of the nasopharyngeal mucosa. It facilitates nasal breathing and patency in rhinitis.

Csimelin Eco contains no preservatives. In therapeutic concentrations it does not irritate the mucosa and does not cause hyperemia. The action occurs within two minutes and lasts for 12 hours.

In vitro studies have shown that xylometazoline suppresses the infectious activity of the human rhinovirus that causes the “common cold.”

Pharmacokinetics. When applied topically, it is practically not absorbed and plasma concentrations are so low that they cannot be determined by modern analytical methods.

Pharmacokinetics.

Indications

Active ingredient

Composition

Csimelin Eco 35 mcg/dose

the active ingredient:
xylomethazoline hydrochloride 35 µg

auxiliary substances:
Sodium hydrophosphate dihydrate 140 µg
Sodium dihydrophosphate dihydrate 140 µg
sodium edetate 35 µg
sodium chloride 518 µg
water purified 69.6 mg

How to take, the dosage

Intranasally.

The product Ximeline Echo, 35 mcg/dose, spray for children from 2 to 10 years: 1 injection in each nasal passage; do not use more than 3 times a day.

The product is used for no more than 5 days, with adult supervision.

Xymelin Eco, 140 mcg/dose, spray for adults and children over 10 years: 1 spray in each nostril (can be repeated if needed); do not use more than 3 times daily.

The product should not be used more than 10 days.

One injection of Xymelin Eco 35 µg/dose contains approximately 35 µg xylometazoline hydrochloride; one injection of Xymelin Eco 140 µg/dose contains approximately 140 µg xylometazoline hydrochloride.

In children, the product should be used under adult supervision.

Perform the product only for the indication, route of administration, and dosage listed in the directions.

The bottle should be held with the nebulizer up when the product is dispensed.

Interaction

Special Instructions

It should not be used in children younger than 2 years.

It is not recommended to use continuously for more than 10 days.

The recommended doses should not be exceeded, especially in children and the elderly.

Long-term (more than 10 days) or excessive use may cause mucosal edema or hypersecretion due to hypersensitivity of the cells (“rebound effect”).

Contraindications

High sensitivity to the drug components, arterial hypertension, tachycardia, marked atherosclerosis, glaucoma, atrophic rhinitis, hyperthyroidism, brain surgery (in anamnesis), pregnancy, children under 2 years of age (for Ximeline Eco 35 mcg/dose); children under 10 years of age (for Ximeline Eco 140 mcg/dose).

Do not use the drug while on therapy with monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants, including a period of 14 days after their withdrawal.

Cautions
Diabetes mellitus; pheochromocytoma; diseases of the cardiovascular system, including CHD, angina pectoris III – IV functional class; porphyria; breast-feeding period; prostatic hyperplasia; atherosclerosis; with hypersensitivity to adrenergic drugs, accompanied by insomnia, dizziness, arrhythmia, tremor, increased blood pressure.

Side effects

Classification of the incidence of adverse reactions: very common (≥ 1/10); common (≥ 1/100, ˂ 1/10); infrequent (≥ 1/1000, ˂ 1/100); rare (≥ 1/10000, ˂ 1/1000); very rare (˂ 1/10000).

Immune system disorders

Very rare: hypersensitivity reactions (angioedema, rash, itching).

Nervous system disorders

Frequently: headache.

Rarely: insomnia, depression (with prolonged use in high doses).

Very rarely: anxiety, fatigue, hallucinations and seizures (mainly in children).

Visual disorders

Very rare: impaired visual clarity.

Heart disorders

Rarely: feeling of palpitation, increased blood pressure.

Very rare: tachycardia, arrhythmia.

Rarely: irritation and/or dry nasal mucosa, burning, tingling, sneezing, hypersecretion of nasophary mucosa.

Infrequent: nasal congestion (reactive hyperemia) (especially with frequent and prolonged use), nasal bleeding.

Gastrointestinal disorders

Frequently: nausea.

Rarely: vomiting.

If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Xylomethasoline may cause severe dizziness, increased and irregular pulse rate, increased sweating, rapid decrease in body temperature, headache, drowsiness, bradycardia, increased blood pressure, respiratory depression, coma, and seizures if administered locally in excessive doses or if taken orally accidentally. Following a rise in blood pressure, there may be a sharp drop in blood pressure. Appropriate supportive measures should be taken at any suspicion of overdose, in some cases immediate symptomatic treatment under medical supervision is indicated.

In cases of severe poisoning with cardiac arrest resuscitation should last at least 1 hour.

Similarities