Xanthinol nicotinate, tablets 150 mg 60 pcs

Pharmacotherapeutic group: Vasodilator.

ATX code: C04AD02.

Pharmacological properties

Pharmacodynamics

Xantinol nicotinate has vasodilator and antiaggregant effects. The drug combines the properties of theophylline and nicotinic acid: causes dilation of peripheral vessels, improves collateral circulation, improves oxygenation, increases oxidative phosphorylation and synthesis of adenosine triphosphate (ATP). Xanthinol nicotinate improves cerebral circulation and reduces cerebral hypoxia. The drug also activates the processes of fibrinolysis, reduces blood viscosity, improves microcirculation.

Pharmacokinetics

Xantinol nicotinate is quickly absorbed in the digestive tract. In the body it dissociates to form xanthinol and nicotinic acid. Nicotinic acid binds to blood proteins by less than 20%. Preclinical studies in mice have shown that nicotinic acid bound to a radioactive isotope accumulates in the liver, kidneys, and adipose tissue. Metabolism of nicotinic acid occurs in the liver. There are two pathways of metabolism of nicotinic acid: 1) formation of nicotinamide-adenindinucleotide (NAD) with subsequent conversion to N-methylnicotinamide and N-methyl-2-pyridone-5 -carboxamide (the main metabolic route when nicotinic acid is taken at low doses) and 2) conjugation with glycine to form nicotinic-ureic acid. Nicotinic acid is excreted in the urine, mainly as metabolites; with repeated administration up to 12% of the taken dose of nicotinic acid is excreted unchanged in the urine.

Indications

Active ingredient

Composition

1 tablet contains
Active substance:
Csantinol nicotinate – 150.0 mg
Additional substances:
lactose – 15.7 mg;
potato starch – 51.3 mg;
calcium stearate – 2.3 mg;
povidone (polyvinylpyrrolidone low molecular weight medical) – 10.7 mg

How to take, the dosage

Interaction

Special Instructions

Xanthinol nicotinate causes a “nicotine-like” syndrome accompanied by hyperaesthesia of the mucous membranes of the nose and mouth (aggravates the sensitivity of olfactory and taste receptors) due to which the smell and taste of alcoholic beverages taken during therapy are perceived sharper and more perverse.

Information on the possible effect of the drug for medical use on the ability to operate vehicles, machinery

Higher doses of the drug may cause dizziness, weakness, arterial hypotension and therefore one should refrain from driving and operating machinery.

Synopsis

Contraindications

Side effects

Xanthinol nicotinate may cause dizziness, decreased blood pressure, general weakness, fever, tingling and reddening of the upper body skin, especially the neck and head, nausea, anorexia, diarrhea. These symptoms usually disappear after 10-20 minutes, do not require special treatment and discontinuation of therapy with this drug. If there are undesirable effects not described in these instructions and the above side effects increase during therapy with this drug, the attending physician should be informed immediately.

The drug causes changes in glucose tolerance, increased activity of “hepatic” transaminases, alkaline phosphatase, hyperuricemia when administered in high doses for a long time.

Overdose

Pregnancy use