Xanthinol nicotinate, 150 mg/ml 2 ml 10 pcs.

The drug combines properties of theophylline and nicotinic acid: causes dilation of peripheral vessels, improves collateral circulation, improves oxygenation and tissue nutrition, increases oxidative phosphorylation and ATP synthesis.

Xanthinol nicotinate improves cerebral blood circulation and reduces cerebral hypoxia.

The drug also activates the processes of fibrinolysis and reduces platelet aggregation.

Indications

– obliterating atherosclerosis;

– endarteritis of lower extremity vessels;

– diabetic angiopathy;

– retinopathies;

– acute thrombophlebitis of superficial and deep veins;

– strombophlebitis syndrome;

– trophic ulcers of the lower extremities:

– bedsores;

– Meniere’s syndrome;

– dermatoses associated with vascular trophic disorder;

– cerebral circulatory disorders.

Active ingredient

Composition

1 ml xanthinol nicotinate 150 mg

Excipients:

d/i water (up to 1 ml).

How to take, the dosage

In acute disorders of the blood supply to tissues the drug is administered in 0.3 g (2 ml of 15% solution) in a single dose 1-3 times/day. Depending on the nature of the disease the dose can be gradually increased to 0.6-0.9 g (4-6 ml of 15% solution) 2-3 times/day. The duration of treatment is 2-3 weeks.

In acute disorders of the peripheral and cerebral circulation Xanthinol nicotinate is administered by IV drops at a rate of 40-50 drops/min. For this purpose, 1.5 g (10 ml of 15% solution) of the drug is diluted in 200-500 ml of 5% glucose solution or in 200 ml of sodium chloride isotonic solution, the resulting infusion mixture is infused by drop infusion for 1.5-4 hours. The infusion may be repeated up to 4 times per day; treatment duration is 5-10 days.

Interaction

In order to avoid a sharp decrease of BP, the drug should not be used simultaneously with hypotensive agents.

The drug should not be combined with therapy with MAO inhibitors, strophantine.

Special Instructions

Xanthinol nicotinate causes nicotine-like syndrome accompanied by nasal and oral mucosal hyperesthesia (increases sensitivity of olfactory and taste receptors) due to which the smell and taste of alcoholic beverages taken during therapy are perceived more acutely and perversely.

Avoid contact of the solution with the eyes or mucous membranes.

Impact on driving and operating machinery

High doses of the drug may cause dizziness, weakness and arterial hypotension; therefore, one should refrain from driving and operating machinery.

Contraindications

– acute heart failure, including. acute myocardial infarction;

– degree IIB-III chronic heart failure;

– mitral stenosis;

– arterial hypotension;

– acute bleeding;

– acute gastric or duodenal ulcer;

– acute renal failure;

– glaucoma;

– childhood;

– I trimester pregnancy;

– individual hypersensitivity to the components of the drug.

Side effects

Xanthinol nicotinate may cause dizziness, decreased BP, general weakness, fever, tingling and reddening of the upper body skin, especially the neck and head, nausea, anorexia, diarrhea.

These symptoms usually disappear after 10-20 minutes and do not require special treatment or discontinuation of therapy with this drug.

If you experience any undesirable effects not described in these instructions and the above side effects increase with therapy with this drug, you should tell your doctor immediately.

The drug causes changes in glucose tolerance, increased hepatic transaminases, alkaline phosphatase activity, and hyperuricemia when administered in high doses for a long time.

Overdose

The drug is mildly toxic.

Symptoms: acute overdose of xanthinol nicotinate is accompanied by arterial hypotension, general weakness, dizziness, tachycardia, abdominal pain and vomiting.

Treatment: in case of symptoms of overdose symptomatic therapy is prescribed.