Vinpocetine-OBL, tablets 5 mg 50 pcs

Vinpocetine is a drug that improves blood circulation and metabolism of the brain, has vasodilator, antihypoxic, anti-aggregation action. It inhibits phosphodiesterase and increases the content of cyclic adenosine monophosphate in cells, which leads to a decrease of calcium in the cytoplasm of smooth muscle cells and relaxation of myofibrils.

Dilates brain vessels, increases blood flow, mainly in ischemic areas, improves the supply of oxygen to the brain.

Promotes glucose utilization and increases catecholamine levels in the central nervous system, stimulates the metabolism of noradrenaline and serotonin in brain tissues. It reduces platelet aggregation and blood viscosity, increases red blood cell deformability and normalizes venous outflow against decreased resistance of cerebral vessels.

Systemic blood pressure slightly decreases. In old age and old age, the sensitivity of cerebral vessels to the relaxing action of Vinpocetine increases due to sensitization of the adenylate cyclic adenosine monophosphate system during aging.

Indications

Acute and chronic cerebral circulatory failure. Discirculatory encephalopathy, accompanied by memory impairment, dizziness, and headache.

Post-traumatic encephalopathy. Vascular diseases of the retina and choroid.

Hearing impairment of vascular or toxic origin, Meniere’s disease, dizziness of labyrinthine origin. Vegetative-vascular dystonia in menopausal syndrome.

Pharmacological effect

Vinpocetine is a drug that improves blood circulation and brain metabolism, has a vasodilator, antihypoxic, and antiaggregation effect. Inhibits phosphodiesterase and increases the content of cyclic adenosine monophosphate in cells, which leads to a decrease in calcium content in the cytoplasm of smooth muscle cells and relaxation of myofibrils.

Dilates brain vessels, increases blood flow, mainly in ischemic areas, improves oxygen supply to the brain.

Promotes the utilization of glucose and increases the level of catecholamines in the central nervous system, stimulates the metabolism of norepinephrine and serotonin in brain tissue. Reduces platelet aggregation, blood viscosity, increases the deformability of erythrocytes and normalizes venous outflow while reducing cerebral vascular resistance.

Systemic blood pressure decreases slightly. In old and senile age, the sensitivity of cerebral vessels to the relaxing effect of Vinpocetine increases, which is due to the sensitization of the adenylate cyclase system – cyclic adenosine monophosphate during aging.

Special instructions

The presence of long QT syndrome and the use of drugs that cause prolongation of the QT interval require periodic ECG monitoring.

In case of lactose intolerance, please note that one tablet contains approximately 225 mg of lactose.

Active ingredient

Vinpocetine

Composition

Active substance – vinpocetine 5 mg;

excipients – potato starch,

milk sugar (lactose),

microcrystalline cellulose,

magnesium stearate,

talc,

colloidal silicon dioxide (aerosil).

Contraindications

acute phase of hemorrhagic stroke, severe coronary heart disease, severe arrhythmias, hypersensitivity to any of the components of the drug.
pregnancy (placental bleeding and spontaneous abortions are possible, probably as a result of increased placental blood supply).
lactation period (when using the drug, you must stop breastfeeding).
children under 18 years of age (due to insufficient data).

Side Effects

From the cardiovascular system: ECG changes (ST depression, QT interval prolongation), tachycardia, extrasystole, blood pressure lability, hot flashes.

From the digestive system: dry mouth, nausea, heartburn.

From the central nervous system: sleep disturbances (insomnia or increased drowsiness), dizziness, headache.

Others: allergic reactions, general weakness, increased sweating.

Interaction

When used concomitantly with warfarin, a slight decrease in the anticoagulant effect of warfarin has been reported.

With simultaneous parenteral use of vinpocetine and heparin, the risk of bleeding may increase.

Overdose

Currently, no cases of overdose of Vinpocetine have been reported.

Treatment: gastric lavage, taking activated carbon; If necessary, carry out symptomatic therapy.

Manufacturer

Alium JSC, Russia