Viagra, 25 mg

VIAGRA is a drug for the treatment of erectile dysfunction. It acts on the natural mechanisms of erection. It is used in men suffering from erectile dysfunction of various origins (vascular, nervous erectile dysfunction).

Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (FDE5).
The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the cavernous body during sexual stimulation.

Nitric oxide activates the enzyme guanylate cyclase, which leads to increased levels of cyclic guanosine monophosphate (cGMP), relaxing the smooth muscles of the cavernous body and increasing blood flow in the penis.

Sildenafil has no direct relaxant effect on the isolated human cavernous body, but actively enhances the relaxant effect of NO on this tissue by inhibiting FDE5, which is responsible for the breakdown of cGMP in the cavernous body.

In sexual arousal, local release of NO under the influence of sildenafil leads to inhibition of FDEF5 and increases cGMP levels in the corpora cavernosa, resulting in relaxation of smooth muscles and increased blood flow in the corpora cavernosa.

The prerequisite for the effectiveness of sildenafil is sexual stimulation.

Indications

Treatment of erectile dysfunction characterized by the inability to achieve or maintain a penile erection sufficient for satisfactory intercourse.

The drug Viagra is effective only in the presence of sexual stimulation.

Active ingredient

Composition

Active substance:

sildenafil (in the form of sildenafil citrate) 25 mg;

excipients:

microcrystalline cellulose,

calcium hydrophosphate (anhydrous),

p> croscarmellose sodium,

magnesium stearate,

Opadry blue and Opadry clear film coatings.

How to take, the dosage

For most patients, the recommended dose is 50 mg; the drug is taken about 1 hour before sexual activity if needed. Depending on efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg.

The maximum recommended dose is 100 mg.
The maximum recommended frequency of use is once daily.

Special Instructions

To diagnose erectile dysfunction, determine its possible causes, and choose an adequate treatment, a complete medical history and a thorough physical examination must be taken. Erectile dysfunction treatments should be used with caution in patients with anatomic penile deformities (angulation, cavernous fibrosis, Peyronie’s disease), or in patients with risk factors for priapism (sickle cell anemia, multiple myeloma, leukemia).

The drugs intended to treat erectile dysfunction should not be prescribed for men for whom sexual activity is undesirable.

Contraindications

– Hypersensitivity to any component of the drug.
– Use in patients receiving nitric oxide donators, organic nitrates or nitrites in any form continuously or intermittently.
– Age under 18 years.
– Not intended for use in women.

With caution: anatomical deformity of the penis (including. angulation, cavernous fibrosis or Peyronne’s disease), diseases predisposing to the development of priapism (such as sickle cell anemia, multiple myeloma. leukemia, thrombocythemia), bleeding disorders, exacerbation of peptic ulcer disease, hereditary retinitis pigmentosa, heart failure, unstable angina pectoris, myocardial infarction, stroke or life-threatening arrhythmias in the last 6 months, hypertension (BP > 170/100 mm Hg) or hypotension (BP < 90/50 mm Hg).

Side effects

Adverse events are usually transient and mild to moderately severe. The frequency of adverse events increases with increasing dose.

In the body in general: asthenia, pain, abdominal pain, back pain, infection, flu-like syndrome.

Cardiovascular system: vasodilation (side effect reported in clinical trials).

Digestive system disorders: diarrhea, nausea.

Muscular system disorders: joint pain, muscle pain.

CNS and peripheral nervous system disorders: dizziness (side effect reported in clinical trials), increased muscle tone, insomnia.

Respiratory system: nasal congestion, pharyngitis, rhinitis (side effect reported in clinical trials), sinusitis, respiratory tract infections, respiratory dysfunction.

Dermatological reactions: rash.

Sensory organs: changes in vision: mild and transient, mainly changes in the color of objects, as well as increased perception of light and blurred vision (side effect reported in clinical trials), conjunctivitis.

Urinary system disorders: urinary tract infections.

Perior genital system disorders: disorders of prostate function.

When using the drug in doses higher than recommended, the side effects were similar to those noted above, but were usually more common.

The following are the adverse events reported during post-marketing use.

Cardiovascular disorders: arterial hypotension, syncope, tachycardia, palpitations.

Digestive system disorders: vomiting (side effect reported in clinical trials).

Anxiety of the sexual system: prolonged erection and/or priapism.

Sensory system disorders: pain in the eyes, redness of the eyes.

Other: allergic reactions.

Pregnancy use

It is not intended for use in women.

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