Vessel Due F, capsules 250 le 60 pcs

Vessel® Due F (sulodexide) is a biological drug which is a natural mixture of glycosaminoglycans (GAGs): a heparin-like fraction with a molecular weight of 8000 dalton (80%) and dermatansulfate (20%).

The mechanism of action of sulodexide is due to two main properties: the fast acting heparin-like fraction has an affinity to antithrombin III (ATIII), and dermatan – to cofactor II heparin (KGII). After oral administration at the recommended dosage, the amount of sulodexide and its derivatives after first-pass effects is sufficient to induce antithrombin action without affecting normal coagulation parameters (activated partial thromboplastin time (APTB), thrombin time, activated factor X). Thus, we can assume that sulodexide when administered orally has no anticoagulation.

Pharmacological action: angioprotective, profibrinolytic, antithrombotic.

Pharmacodynamics

Angioprotective effect is associated with the restoration of structural and functional integrity of vascular endothelial cells, with the restoration of the normal density of the negative electric charge of the basal membrane pores of blood vessels. Besides, the preparation normalizes rheological blood properties due to reduction of triglycerides level (it stimulates lipolytic enzyme – lipoprotein lipase – that hydrolyzes triglycerides being a part of LDL).

The effectiveness of the drug in diabetic nephropathy is determined by the ability of sulodexide to reduce the thickness of the basal membrane and extracellular matrix production by reducing the proliferation of mesangium cells.

Profibrinolytic effect is due to the increase in blood levels of tissue plasminogen activator and reduction of its inhibitor.

The antithrombotic activity of oral sulodexide is mainly the result of all the effects that sulodexide has on the vascular wall (angioprotective effect), fibrinolysis (profibrinolytic effect) and inhibition of platelet adhesion.

Pharmacokinetics

Sulodexide is absorbed in the small intestine. After ingestion of the labeled drug, the first peak of sulodexide in plasma is observed in 2 hours, the second in 4 to 6 hours, after which the drug is no longer detectable in plasma; concentrations recover after about 12 hours and then remain constant until about the 48th hour. Permanent plasma levels are detected after 12 hours, probably due to the slow release of the drug by the absorptive organs and in particular by the vascular endothelium. Sulodexide is distributed in the vascular endothelium at a concentration 20-30 times higher than in other tissues. It is metabolized in the liver and excreted mainly by the kidneys. In a study of radioactive labeled drug 55.23% of sulodexide was excreted with urine during the first 96 hours.

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Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Due to the pharmaco-toxicological properties of sulodexide, the use of the drug does not require special precautions. However, when combined with other anticoagulants, blood clotting parameters should be periodically monitored.

Effect on the ability to drive and operate vehicles

Vessel® Due F has no effect on the ability to drive and operate vehicles.

Contraindications

Side effects

Overdose