Vertum Lor, spray 0.255 mg/dose 40 ml

Pharmacotherapeutic group

Non-steroidal anti-inflammatory drug.

ATC code

A01AD02

Pharmacological properties

Pharmacodynamics

Benzidamine is a non-steroidal anti-inflammatory drug, belongs to the group of indazoles. It has anti-inflammatory and local analgesic effect, has antiseptic action against a wide range of microorganisms.

The mechanism of action of the drug is associated with stabilization of cell membranes and inhibition of prostaglandin synthesis.

Benzidamine has antibacterial and specific antimicrobial action due to rapid penetration through the membranes of microorganisms with subsequent damage of cell structures, disruption of metabolic processes and cell lysosomes.

It has antifungal action against Candida albicans. Causes structural modifications of the cell wall of fungi and their metabolic chains, thus preventing their reproduction, which was the basis for use of benzidamine in inflammatory processes in the oral cavity, including infectious etiology.

Pharmacokinetics

When used topically, benzidamine is well absorbed through mucous membranes and penetrates inflamed tissues, being detected in blood plasma in amounts insufficient to produce systemic effects.

The excretion of benzidamine occurs mainly by the kidneys in the form of inactive metabolites or conjugation products.

Indications

Symptomatic treatment of pain syndrome of inflammatory diseases of the oral cavity and ENT organs (of various etiologies):

pharyngitis, laryngitis, tonsillitis;
gingivitis, glossitis, stomatitis (including after radiation and chemotherapy);
periodontal disease;
calculous inflammation of the salivary glands;
after treatment or tooth extraction;
after surgical interventions and injuries (tonsillectomy, jaw fractures);
candidiasis of the oral mucosa (as part of combination therapy).

For infectious and inflammatory diseases requiring systemic treatment, the drug VERTUM ENT is used as part of combination therapy.

Pharmacological effect

Pharmacotherapeutic group

Non-steroidal anti-inflammatory drug.

ATX code

A01AD02

Pharmacological properties

Pharmacodynamics

Benzidamine is a non-steroidal anti-inflammatory drug that belongs to the indazoles group. It has an anti-inflammatory and local analgesic effect, and has an antiseptic effect against a wide range of microorganisms.

The mechanism of action of the drug is associated with the stabilization of cell membranes and inhibition of prostaglandin synthesis.

Benzidamine has an antibacterial and specific antimicrobial effect due to rapid penetration through the membranes of microorganisms with subsequent damage to cellular structures, disruption of metabolic processes and cell lysosomes.

Has antifungal effect against Candida albicans. Causes structural modifications of the cell wall of fungi and their metabolic chains, thus preventing their reproduction, which was the basis for the use of benzydamine for inflammatory processes in the oral cavity, including infectious etiology.

Pharmacokinetics

When applied topically, benzydamine is well absorbed through the mucous membranes and penetrates into inflamed tissues; it is found in the blood plasma in quantities insufficient to produce systemic effects.

Excretion of benzydamine occurs mainly by the kidneys in the form of inactive metabolites or conjugation products.

Special instructions

When using benzydamine, hypersensitivity reactions may develop. In this case, it is recommended to stop treatment and consult a doctor to prescribe appropriate therapy.

In a limited number of patients, the presence of ulcers in the throat and mouth may indicate a more serious condition. If symptoms persist for more than 3 days, you should consult your doctor.

The use of benzydamine is not recommended in patients with hypersensitivity to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs.

The drug should be used with caution in patients with a history of bronchial asthma due to the possibility of developing bronchospasm in them while taking benzydamine.

The drug contains parahydroxybenzoates, which can cause allergic reactions.

Impact on the ability to drive vehicles and machinery

The drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Benzydamine

Composition

1 dose of spray contains:

active ingredient: benzydamine hydrochloride – 0.255 mg.

excipients: ethanol (ethyl alcohol 95%) – 13.6 mg, glycerol (glycerin)

– 8.5 mg; methyl parahydroxybenzoate (methylparaben) – 0.17 mg; natural food flavor MINT* – 0.051 mg; sodium saccharinate – 0.0408 mg; polysorbate 20 – 0.0085 mg; purified water – up to 0.17 ml.

*Ingredients: natural food flavoring, propylene glycol. The propylene glycol content in 1 ml of solution is less than 0.3 mg.

Pregnancy

The use of benzydamine during pregnancy and breastfeeding is not recommended.

Contraindications

Hypersensitivity to benzydamine or any other component of the drug;
children under 3 years of age.

With caution

hypersensitivity to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs;
bronchial asthma (including history).

Side Effects

Classification of the incidence of side effects according to the recommendations of the World Health Organization (WHO):
very often ≥ 1/10;
often from ≥ 1/100 to < 1/10; infrequently from ≥ 1/1000 to < 1/100; rarely from ≥ 1/10000 to < 1/1000;
very rare <1/10000, including individual reports;
frequency unknown – based on available data, it is not possible to determine the frequency of occurrence.

Immune system disorders:
uncommon – photosensitivity;
rarely – hypersensitivity reactions, skin rash, itching; very rarely – angioedema, laryngospasm;
frequency unknown – anaphylactic reactions.

General disorders and reactions at the injection site:
rarely – dry mouth, burning sensation in the mouth; frequency unknown – feeling of numbness in the mouth.
If any of the side effects indicated in the instructions worsen, or any other side effects not listed in the instructions are noted, you should immediately inform your doctor.

Interaction

No interaction studies have been conducted with other drugs.

Overdose

No cases of benzydamine overdose have been reported.
When using the drug in accordance with the instructions for use, an overdose is unlikely.

Symptoms
If the drug is accidentally ingested, the following symptoms are possible: vomiting, abdominal cramps, anxiety, fear, hallucinations, convulsions, ataxia, fever, tachycardia, respiratory depression.

Treatment
Treatment is symptomatic. Empty the stomach by inducing vomiting or flush the stomach using a gastric tube (under medical supervision); provide medical supervision, supportive care and necessary hydration. No antidote is known.

Storage conditions

At a temperature not exceeding 25 °C. Keep out of the reach of children.

Shelf life

3 years.
Do not use after expiration date.

Manufacturer

Vertex, Russia