Vero-epoetin lyophilizate 2 thousand IU

Epoietin beta is a glycoprotein that specifically stimulates erythropoiesis, activates mitosis and maturation of erythrocytes from erythrocyte precursor cells.

Indications

Symptomatic anemia in chronic kidney disease in patients on dialysis.

Symptomatic anemia of renal origin in patients not yet receiving dialysis. Prevention and treatment of anemia in patients with solid tumors, whose anemia was a consequence of antitumor therapy.

Prevention and treatment of anemia in HIV-infected patients (AIDS) caused by the use of Zidovudine.

Prevention and treatment of anemia in patients with multiple myeloma, low-grade non-Hodgkin lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis.

Treatment and prevention of anemia in premature infants born with low body weight up to 1.5 kg.

To reduce the volume of blood transfused during major surgical interventions and acute blood loss.

Pharmacological effect

Epoetin beta is a glycoprotein that specifically stimulates erythropoiesis, activates mitosis and maturation of erythrocytes from erythrocyte precursor cells.

Special instructions

During treatment, it is necessary to monitor blood pressure weekly and perform a complete blood count, including determination of hematocrit, platelets and ferritin. In patients with uremia on hemodialysis, due to an increase in hematocrit, it is often necessary to increase the dose of heparin; in addition, timely prevention of thrombosis and early revision of the shunt are necessary.

Active ingredient

Epoetin beta

Composition

Recombinant Human Erythropoietin 1000 IU 2000 IU 4000 IU 10000 IU,

Contraindications

Hypersensitivity to the drug or its components, partial red cell aplasia after previous therapy with any erythropoietin, uncontrolled hypertension, failure to receive adequate anticoagulant therapy, myocardial infarction within a month after the event, unstable angina, or increased risk of deep vein thrombosis and thromboembolism as part of a preoperative blood collection program before surgery operations, porphyria.

With caution:
In patients with thrombosis (history), with malignant neoplasms, with sickle cell anemia, in patients with moderate anemia without iron deficiency, in patients with refractory anemia, epilepsy and chronic liver failure.

Side Effects

cardiovascular system: the emergence or intensification of existing arterial hypertension, especially in the case of a rapid increase in hematocrit; hypertensive crisis with symptoms of encephalopathy (headaches and confusion, sensory and motor disorders – speech disorders, gait, up to tonic-clonic convulsions);

Interaction

With simultaneous use of cyclosporine, it may be necessary to adjust the dose of the latter due to an increase in its binding to erythrocytes.

Experience in the clinical use of Vero-epoetin to date has not revealed any evidence of its pharmacological incompatibility with other drugs.

Overdose

In case of an overdose of Vero-epoetin, increased side effects may occur.

Storage conditions

In a dry place, protected from light, at a temperature of 2 °C to 8 °C.

Shelf life

2 years.

Manufacturer

Veropharm LLC, Russia