Vazoket, tablets 600 mg 30 pcs

Pharmacotherapeutic group: venotonic and venoprotective agent.

TATX code: [C05CA03]

Pharmacological properties

Pharmacodynamics

Diosmin has venotonic action (reduces vein distensibility, increases venous tone (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), It improves microcirculation (increases capillary resistance (dose-dependent effect), decreases their permeability), reduces leukocyte adhesion to the venous wall and their migration to paravenous tissue, improves oxygen diffusion and perfusion in the skin tissue, has anti-inflammatory effect. It enhances the vasoconstrictor effect of adrenaline, noradrenaline, serotonin, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane. .

Pharmacokinetics

After oral administration, the drug is rapidly absorbed from the gastrointestinal tract and determined in blood plasma after 2 hours. The maximum plasma concentration is reached 5 hours after ingestion. It is evenly distributed and accumulated in all layers of the wall of the hollow veins and subcutaneous veins of the lower limbs, to a lesser extent in the kidneys, liver, lungs and other organs. Selective accumulation of diosmin and/or its metabolites in the venous vessels reaches a maximum by 9 hours after intake and persists for 96 hours. Diosmin is excreted by the kidneys 79%, by the intestine – 11%, with the bile – 2.4%.

Indications

Varicose veins of the lower extremities, chronic lymphovenous insufficiency of the lower extremities; exacerbation of hemorrhoids; microcirculatory disorders.

Active ingredient

Composition

Active ingredient:

diosmin 600 mg.

Auxiliary substances: povidone, microcrystalline cellulose, corn starch, magnesium stearate.

How to take, the dosage

When varicose veins of the lower extremities and in the initial stage of chronic lymphovenous insufficiency (heaviness in legs) prescribe 1 tablet a day in the morning before breakfast for 2 months, with severe forms of chronic lymphovenous insufficiency (edema, pain, cramps, etc.) – treatment continues for 3-4 months, with trophic changes and ulcers treatment is extended to 6 months or more. The course of treatment shall be repeated in 2-3 months.

In case of exacerbation of hemorrhoids the drug is prescribed for 2-3 tablets a day with meals for 7 days and then, if necessary, it can be continued for 1 tablet 1 time a day for 1-2 months.

In the treatment of chronic lymphovenous insufficiency during II and III trimester of pregnancy it is prescribed 1 tablet once a day and it is discontinued 2-3 weeks before delivery.

If you miss one or more doses, continue using the drug in the usual dosage.

Interaction

Special Instructions

The treatment of exacerbation of hemorrhoids is carried out in combination with other drugs; in the absence of rapid clinical effect it is necessary to conduct additional examination and adjust the current therapy.

There is evidence of possible effectiveness of the drug in the treatment of fetoplacental insufficiency, for prevention of bleeding arising from the use of IUDs and during phlebectomy.

Synopsis

Oblong grayish-yellow to light yellow tablets with a break line on both sides.

Contraindications

High sensitivity to the components of the drug, children (under 18 years).

Side effects

In rare cases, gastrointestinal tract – dyspeptic disorders.

The central nervous system – headache.

Overdose

Symptoms of overdose have not been described.

Pregnancy use

Similarities