Validol with glucose, 20 pcs.

Pharmacodynamics

Validol has a calming effect on the central nervous system, as well as a moderate reflex vasodilator effect due to irritation of the sensitive nerve endings.

Stimulates the production and release of enkephalins, endorphins and other peptides, histamine, kinins (by irritating the receptors of the oral mucosa), which actively participate in the regulation of vascular permeability and pain.

When administered sublingually the therapeutic effect occurs on average in 5 minutes with up to 70% of the drug released within 3 minutes.

Pharmacokinetics

Sublingual administration is absorbed from the oral mucosa, metabolized in the liver, excreted in the urine as glucuronides.

Indications

Functional cardialgia, neuroses, motion sickness syndrome (nausea, vomiting due to sea and air sickness).

Pharmacological effect

Pharmacodynamics

Validol has a calming effect on the central nervous system, as well as a moderate reflex vasodilator effect due to irritation of sensitive nerve endings.

Stimulates the production and release of enkephalins, endorphins and a number of other peptides, histamine, kinins (due to irritation of receptors in the oral mucosa), which are actively involved in the regulation of vascular permeability and the formation of pain.

When taken sublingually, the therapeutic effect occurs, on average, within 5 minutes, with up to 70% of the drug released within 3 minutes.

Pharmacokinetics

When administered sublingually, it is absorbed from the oral mucosa, metabolized in the liver, and excreted in the urine in the form of glucuronides.

Active ingredient

Levomenthol solution in menthyl isovalerate, (Dextrose)

Composition

For one tablet:
active substance:
levomenthol solution in menthyl isovalerate (validol) – 0.060 g
dextrose (glucose) monohydrate – 0.188 g
excipients:
sucrose (sugar) – 0.544 g
calcium stearate – 0.008 g

Contraindications

Hypersensitivity to the components of the drug, impaired tolerance to carbohydrates. Sucrose/isomaltose deficiency, glucose-galactose malabsorption; age up to 18 years (efficacy and safety have not been established).
With caution:
Diabetes mellitus.

Side Effects

With long-term use, mild nausea, lacrimation, and dizziness may occasionally occur. These phenomena usually go away on their own.

Interaction

When used together with other drugs that depress the central nervous system, it enhances the effect of the latter. Simultaneous use of the drug with nitrates reduces the headache that occurs when using them.

Overdose

Symptoms: headache, nausea, agitation, decreased blood pressure, depression of the central nervous system.
Treatment: drug withdrawal, symptomatic therapy.

Manufacturer

Update of PFC JSC, Russia