Urofuragin, tablets 50 mg 30 pcs

A broad-spectrum antimicrobial, belongs to the group of nitrofurans. The mechanism of action is associated with inhibition of nucleic acid synthesis. Under the influence of nitrofurans there is inhibition of respiratory chain activity and tricarboxylic acid cycle (Krebs cycle), as well as inhibition of other biochemical processes of microorganisms, which leads to destruction of their shell or cytoplasmic membrane.

Active against Gram-positive cocci: Staphylococcus spp, Streptococcus spp.; Gram-negative bacilli: Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp.
Resistant to furazidine: Pseudomonas aeruginosa, Enterococcus spp., Acinetobacter spp, most strains of Proteus spp., Serratia spp.

Depending on the concentration has a bactericidal or bacteriostatic effect. Bacteriostatic concentration varies from 10 to 20 microgram/ml against most bacteria. Bactericidal concentration is approximately 2 times higher.

Pharmacokinetics

Absorption

Absorbed from small intestine by passive diffusion. Absorption of nitrofurans from the distal segment of the small intestine exceeds absorption from the proximal and medial segments by a factor of 2 and 4, respectively. It is poorly absorbed from the large intestine. Cmax in serum persists from 3 to 7-8 h.

Distribution

Distributes evenly.
In high concentrations it is found in lymph; in bile its concentration is several times higher than in serum, in cerebrospinal fluid it is several times lower than in serum; saliva contains up to 30% of its concentration in serum; in blood and tissues its concentration is low, due to its rapid excretion, while its concentration in urine is much higher than in blood.

Metabolism and excretion

Metabolized in the liver (less than 10%), with decreased renal excretory function the intensity of metabolism increases.

In the urine detected after 3-4 hours. Unlike nitrofurantoin it does not change pH in urine.

It is excreted by kidneys by glomerular filtration and tubular secretion (85%), partially undergoes reverse reabsorption in tubules.
At low concentrations in urine filtration and secretion prevail, at high concentrations secretion decreases and reabsorption increases.
Being a weak acid it does not dissociate; at acidic values of urine pH it undergoes intensive reabsorption, which may increase systemic side effects.

Indications

Urethritis, inflammation of female genitals – treatment of infectious and inflammatory diseases of the urinary tract (cystitis, urethritis, pyelonephritis), caused by microorganisms sensitive to furazidine;
– prevention of infectious complications after surgical interventions on the genitourinary system.

Active ingredient

Furazidine

Composition

1 tablet:

Furazidine 50 mg

Excipients:corn starch – 27.5 mg, sucrose – 13.75 mg.

How to take, the dosage

The drug is taken orally, after meals.

For treatment, 100-200 mg 2-3 times a day for 7-10 days. If necessary, after a 10-15 day break the treatment course is repeated. Maximum daily dose is 600 mg.

To prevent infectious complications after surgical interventions on the genitourinary system it is used once in 50 mg 30 min before the surgery.

Interaction

Concomitant use with ristomycin, chloramphenicol, sulfonamides increases the risk of hematotoxic effect.

Simultaneous use of other nitrofuran derivatives and urine acidifying drugs (including ascorbic acid, calcium chloride) should be avoided.

Drugs that alkalize the urine accelerate excretion of furazidine with the urine.

Ethanol may increase the severity of side effects.

Probenecid and sulfinpyrazone decrease urinary excretion of furazidine.

This may lead to cumulation of furazidine and increase its toxicity.

Concomitant use of magnesium-containing antacids decreases absorption of furazidine.

Special Instructions

To prevent the development of side effects, plenty of drinking is prescribed.

To prevent the development of neuritis it is necessary to prescribe B-group vitamins.

When using the drug the urine is stained brown.

Long-term use of the drug requires monitoring of peripheral blood count, renal function, liver and lungs.

False positive results are possible while determining glucose in urine by enzymatic methods.

When using the drug the development of diarrhea caused by Clostridium difficile (pseudomembranous colitis) is possible.

In mild cases the drug withdrawal is sufficient, in severe cases the appropriate treatment should be prescribed.

Do not use drugs that inhibit intestinal peristalsis.

Effect on the ability to drive vehicles and operate machinery

During the treatment you should refrain from driving vehicles and engaging in other activities that require high concentration and rapid psychomotor reactions.

Contraindications

– impaired renal function;

– urosepsis and infections of the renal parenchyma;

– impaired liver function;

– pregnancy;

– breastfeeding period;

– childhood and adolescence under 18 years of age;

– Lactase, sucrose/isomaltase deficiency, lactose intolerance, fructose intolerance, glucose-galactose malabsorption;

– hypersensitivity to furazidine, other components of the drug;

– hypersensitivity to nitrofuran derivatives.

With caution the drug should be used in case of anemia, lung diseases (especially in patients older than 65 years), nervous system diseases, diabetes, porphyria, deficiency of glucose-6-phosphate dehydrogenase, vitamin B group and folic acid.

Side effects

Hematopoietic system disorders: agranulocytosis, thrombocytopenia, aplastic anemia, eosinophilia.

Nervous system disorders:dizziness, headache, drowsiness, weakness, peripheral neuropathy, development of polyneuritis.

Visual organ: visual impairment.

Cardiovascular system disorders:intracranial hypertension.

In the respiratory system:dyspnea, chest pain, cough with or without sputum, interstitial pneumonitis, pulmonary fibrosis.

Digestive system: nausea, vomiting, decreased appetite, anorexia, diarrhea, pancreatitis, impaired liver function, cholestatic jaundice, hepatitis.

Muscular system disorders: myalgia, arthralgia.

Skin and subcutaneous tissue:cutaneous rash (including papular), enanthema, pruritus, exfoliative dermatitis, reversible alopecia.

Allergic reactions: angioedema, urticaria, erythema multiforme.

Others:fever.

Overdose

Symptoms:neurotoxic reactions, polyneuritis, liver dysfunction, acute toxic hepatitis.

Treatment:drug withdrawal, taking plenty of fluids, symptomatic therapy, antihistamines, B vitamins.

There is no specific antidote.

Similarities

Furamag, Furasol, Furagin, Furagin-Actifur