Unityol,. 50 mg/ml 5 ml 10 pcs

Unithiol is a complexing agent and has a detoxifying effect.

The active sulfhydryl groups of unitiol interacting with thiol poisons (arsenic compounds, heavy metal salts) and forming with them non-toxic, water-soluble compounds, restore functions of the enzyme systems of the body which are affected by the poison.

In diabetic polyneuropathy, it reduces pain syndrome, improves the condition of the peripheral nervous system and normalizes capillary permeability.

Pharmacokinetics

Absorption

In parenteral administration the drug is quickly absorbed into the blood. The maximum level of the drug in the blood (C max ) is reached 15-30 min after the intravenous injection.

The elimination half-life (T 1/2 ) is 1-2 hours. It is excreted by the kidneys, mainly as products of incomplete and complete oxidation, partially unchanged.

Indications

Alcoholism, Polyneuropathy

• intoxication with arsenic, mercury, bismuth, chromium, cardiac glycosides;
• .Hepatocerebral dystrophy (Wilson-Westphal-Conoval disease);
• chronic alcoholism (as part of complex therapy),
• alcoholic delirium.

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Active ingredient

Sodium dimercaptopropane sulfonate

Composition

1 ml of solution for intramuscular and subcutaneous injection contains:

active ingredients:

dimercaptopropanesulfonate sodium monohydrate (unitiol) 50 mg;

auxiliary substances:

dinatrium edetate (trilon B),

sulfuric acid 0.1 M (to pH 3.1-4.5),

d/i water.

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How to take, the dosage

Unityol is used intramuscularly or subcutaneously.

• In intoxication with arsenic – 5-10 ml of the drug (at the rate of 0.005 g/1 kg), in the 1st day – 3-4 times, 2nd day – 2-3 times, in subsequent days – 1-2 times.
• In intoxication with mercury compounds – on the same schedule for 6-7 days. The treatment is carried out until signs of intoxication disappear.
• In case of digitalis intoxication during the first 2 days the drug is injected 5-10 ml of 5% aqueous solution 3-4 times a day, then 1-2 times a day until cardiotoxic effect is cured.
• Hepatocerebral dystrophy – 5-10 ml of 5% solution daily or every other day; treatment course – 25-30 injections; repeated in 3-4 months if necessary.
• In chronic alcoholism 3-5 ml 2-3 times a week.
• For treatment of delirium – once 4-5 ml.

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Interaction

The simultaneous use of Unityol with drugs containing heavy metals and alkalis is not recommended because Unityol decomposes quickly.

Special Instructions

In acute poisoning, additional therapeutic measures (gastric lavage, oxygen therapy, administration of dextrose, etc.) are carried out.

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Contraindications

• high sensitivity to Unityol,
• hepatic insufficiency,
• arterial hypertension.

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Side effects

• nausea,
• dizziness,
• tachycardia,
• pale skin,
• possible allergic reactions.

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Overdose

Symptoms: dyspnea, hyperkinesias, lethargy, lethargy, stunned, short-term seizures (occurs when the recommended therapeutic dose is exceeded by more than 10 times).

Treatment: symptomatic therapy.

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