Unityol,. 50 mg/ml 5 ml 10 pcs

Unithiol is a complexing agent and has a detoxifying effect.

The active sulfhydryl groups of unitiol interacting with thiol poisons (arsenic compounds, heavy metal salts) and forming with them non-toxic, water-soluble compounds, restore functions of the enzyme systems of the body which are affected by the poison.

In diabetic polyneuropathy, it reduces pain syndrome, improves the condition of the peripheral nervous system and normalizes capillary permeability.

Pharmacokinetics

Absorption

In parenteral administration the drug is quickly absorbed into the blood. The maximum level of the drug in the blood (C max ) is reached 15-30 min after the intravenous injection.

The elimination half-life (T 1/2 ) is 1-2 hours. It is excreted by the kidneys, mainly as products of incomplete and complete oxidation, partially unchanged.

Indications

intoxication with arsenic, mercury, bismuth, chromium, cardiac glycosides;
hepatocerebral dystrophy (Wilson-Westphal-Konovalov disease);
chronic alcoholism (as part of complex therapy),
alcoholic delirium.

Pharmacological effect

Unithiol is a complexing agent that has a detoxifying effect.

The active sulfhydryl groups of unithiol, interacting with thiol poisons (arsenic compounds, heavy metal salts) and forming non-toxic, water-soluble compounds with them, restore the functions of the body’s enzyme systems affected by the poison.

In diabetic polyneuropathy, it reduces pain, improves the condition of the peripheral nervous system and normalizes capillary permeability.

Pharmacokinetics

Suction

When administered parenterally, it is quickly absorbed into the blood. The maximum level of the drug in the blood (Cmax) is achieved 15-30 minutes after IM injection.

Removal

The half-life (T 1/2) is 1-2 hours. It is excreted by the kidneys, mainly in the form of products of incomplete and complete oxidation, partially unchanged.

Special instructions

In case of acute poisoning, additional therapeutic measures are carried out (gastric lavage, oxygen therapy, administration of dextrose, etc.).

Active ingredient

Sodium dimercaptopropanesulfonate

Composition

1 ml of solution for intramuscular and subcutaneous administration contains:

active substances:

sodium dimercaptopropanesulfonate monohydrate (unithiol) 50 mg;

excipients:

disodium edetate (trilon B),

sulfuric acid 0.1 M (up to pH 3.1-4.5),

water d/i.

Contraindications

hypersensitivity to the drug Unithiol,
liver failure,
arterial hypertension.

Side Effects

nausea,
dizziness,
tachycardia,
pale skin,
Allergic reactions are possible.

Interaction

The simultaneous use of Unithiol with drugs that contain heavy metals and alkalis is not recommended, as Unithiol rapidly decomposes.

Overdose

Symptoms: shortness of breath, hyperkinesis, lethargy, lethargy, stupor, short-term convulsions (occur when the recommended therapeutic dose is exceeded by more than 10 times).

Treatment: symptomatic therapy.

Storage conditions

Store in a place protected from light at a temperature of 0 to 25 °C. Do not freeze.

Shelf life

5 years.

Manufacturer

Yerevan HFF, Armenia