Triderm, ointment 15 g

Pharmacological group: glucocorticosteroid + antibiotic aminoglycoside + antifungal agent.

Pharmacological action:

Triderm is a combination drug,.
The Triderm® ointment and cream combine the anti-inflammatory, antipruritic, anti-allergic and anti-exudative effects of betamethasone dipropionate with the antifungal activity of clotrimazole and the broad antibacterial action of gentamicin sulfate.

Clotrimazole has antifungal action (inhibits the synthesis of the cell membrane ergosterol of fungi). It is active against Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furfur (Pityrosporum orbiculare).

Gentamicin sulfate, a broad-spectrum antibiotic of the aminoglycoside group, acts bactericidally and provides highly effective local treatment of primary and secondary bacterial skin infections.

Active against Gram-negative microorganisms: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; Gram-positive microorganisms: Streptococcus spp. (sensitive strains of alpha- and beta-hemolytic Streptococcus group A), Staphylococcus aureus (coagulase-positive, coagulase-negative and some strains producing penicillinase).

Indications

Active ingredient

Composition

1 g of ointment contains:

betamethasone 0.5 mg,

clotrimazole 10 mg,

gentamicin 1 mg.

Excipients:

liquid paraffin (50 mg),

white petroleum jelly (q.s. ad 1000).

How to take, the dosage

Interaction

Special Instructions

It should not be used in ophthalmic practice.

Long-term topical use of antibiotics can sometimes lead to the growth of resistant microflora. If this occurs and if irritation, sensitization or superinfection occurs with Topicale®Triderm® , treatment should be discontinued and an appropriate therapy should be prescribed.

Cross-allergic reactions with aminoglycoside antibiotics have been observed.

Any side effects common with systemic glucocorticosteroids, including inhibition of adrenal function, can also be seen with topical glucocorticosteroid use, particularly in children.

The systemic absorption of glucocorticosteroids or gentamicin when applied topically will be greater if treatment is given over a larger body surface or if occlusive dressings are used.

Application of gentamicin to open wounds or skin injuries should be avoided. Appropriate precautions should be taken in such cases, especially when treating children.

The withdrawal of the drug after long-term use is recommended to be done gradually.

Pediatric use: In children from 2 years of age only with strict indications and under medical supervision, because of possible systemic side effects associated with betamethasone.

The use of Triderm, as well as many other topical glucocorticosteroids on large surfaces and/or with an occlusive dressing may suppress hypothalamic-pituitary-adrenal system function, there may be a decrease in growth hormone excretion, as well as increased intracranial pressure.

Contraindications

– hypersensitivity to any of the components of the drug Trident;

– tuberculosis of the skin;

– cutaneous manifestations of syphilis;

– chicken pox;

– herpes simplex;

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– skin postvaccination reactions;

– age less than 2 years.

Side effects

Overdose

Pregnancy use

Similarities