Trichopol, vaginal tablets 500 mg 10 pcs

How to take, the dosage

In trichomonas vaginitis the drug is prescribed on 1 vaginal tablet per day for 7-10 days in combination with the drug metronidazole in tablets.

In cases of non-specific vaginitis, bacterial vaginosis the drug is prescribed 1 vaginal tablet daily for 7 days and if necessary in combination with the administration of metronidazole tablets.

The treatment with metronidazole should not last more than 10 days and should be repeated more often than 2 or 3 times a year.

The vaginal tablet should be taken out of the contour pack, moistened with boiled, cooled water, and inserted deep into the vagina.

Interaction

The drug is compatible with sulfonamides and antibiotics.

Metronidazole causes ethanol intolerance, so alcohol should be avoided during treatment.

Metronidazole should not be combined with disulfiram, because the interaction of these drugs may lead to depressed consciousness and mental disorders.

When used concomitantly with indirect anticoagulants (including warfarin), metronidazole increases their effect, which leads to prolongation of the prothrombin time.

The use of metronidazole in combination with nondepolarizing myorelaxants (vecuronium bromide) is not recommended.

Barbiturates may decrease the effectiveness of metronidazole due to its accelerated metabolism in the liver.

Cimetidine inhibits metabolism of metronidazole, which may increase its plasma concentrations and increase the risk of adverse reactions.

Concomitant use with lithium preparations may increase its plasma concentrations.

Special Instructions

The simultaneous treatment with metronidazole by a sexual partner is recommended, regardless of whether he or she has manifestations of the disease.

At the time of treatment with the drug, it is recommended to refrain from sexual intercourse.

In case of a history of changes in peripheral blood counts and when the drug is used in high doses and/or when treatment is prolonged, it is necessary to monitor the total blood count.

Metronidazole may cause immobilization of treponemes, which leads to false-positive Nelson’s test (TPI) results.

Impact on driving and operating machinery

The possibility of dizziness should be considered when prescribing the drug to patients engaged in potentially hazardous activities (especially drivers of vehicles).

Contraindications

• blood disease;
• leukopenia (including anamnesis);
• disorder of motion coordination;
• organic CNS lesions (including epilepsy;
• hepatic failure (high doses). epilepsy);
• hepatic insufficiency (for administration in high doses);
• pregnancy (1st trimester);
• lactation (breastfeeding);
• High sensitivity to metronidazole or other nitroimidazole derivatives.

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Side effects

Local reactions: itching, burning, pain and irritation in the vagina; thick, white, mucous vaginal discharge (odorless or faintly smelling), frequent urination; after drug withdrawal – development of vaginal candidiasis.

Digestive system disorders: nausea, change in taste, metallic taste in the mouth, dry mouth, decreased appetite, spastic abdominal pain, nausea, vomiting, constipation or diarrhea.

CNS disorders: headache, dizziness.

Hematopoietic system disorders: leukopenia or leukocytosis.

Allergic reactions: urticaria, skin itching, rash.

Others: rarely, red-brown coloring of urine due to the presence of water-soluble pigment formed as a result of metabolism of metronidazole; burning sensation or irritation of the penis in the sexual partner.

Overdose

No data on overdose of Trichopol® were provided.

Pregnancy use

Trichopol is contraindicated for use in the first trimester of pregnancy. Use of the drug in the second and third trimesters is possible only in cases when the estimated benefit to the mother exceeds the potential risk to the fetus.

If it is necessary to use Trichopolol during lactation, breastfeeding should be discontinued.

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Similarities

Flagil, Metrogil, Trichopol, Metronidazole, Rosamet, Metronidazole-Acos, Metronidazole Renewal