Trichopol, vaginal tablets 500 mg 10 pcs

Antiprotozoal drug with antibacterial activity, a derivative of 5-nitroimidazole. Mechanism of action consists in biochemical reduction of 5-nitrogroup of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitrogroup of metronidazole interacts with the DNA of the microbial cell, inhibiting the synthesis of their nucleic acids, which leads to the death of the microorganisms.

Metronidazole is active against Trichomonas vaginalis, Entamoeba histolytica, Gardnerella vaginalis, Giardia intestinalis, Lamblia spp.Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp, Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens); some Gram-positive microorganisms (Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.) The MPC for these strains is 0.125-6.25 µg/ml.

In combination with amoxicillin it shows activity against Helicobacter pylori (amoxicillin suppresses the development of resistance to metronidazole).

Metronidazole has no bactericidal effect against most bacteria and facultative anaerobes, fungi and viruses. In the presence of mixed flora (aerobes and anaerobes) metronidazole shows synergism with antibiotics effective against common aerobes.

Metronidazole increases the sensitivity of tumors to radiation, causes sensitization to ethanol (disulfiram-like action), stimulates reparative processes.

Indications

For local treatment:

Active ingredient

Composition

1 tabletcametronidazole 500 mg

Associated substances:

microcrystalline cellulose,

povidone,

Crospovidone,

silicon dioxide colloidal,

stearic acid.

How to take, the dosage

In trichomonas vaginitis the drug is prescribed on 1 vaginal tablet per day for 7-10 days in combination with the drug metronidazole in tablets.

In cases of non-specific vaginitis, bacterial vaginosis the drug is prescribed 1 vaginal tablet daily for 7 days and if necessary in combination with the administration of metronidazole tablets.

The treatment with metronidazole should not last more than 10 days and should be repeated more often than 2 or 3 times a year.

The vaginal tablet should be taken out of the contour pack, moistened with boiled, cooled water, and inserted deep into the vagina.

Interaction

The drug is compatible with sulfonamides and antibiotics.

Metronidazole causes ethanol intolerance, so alcohol should be avoided during treatment.

Metronidazole should not be combined with disulfiram, because the interaction of these drugs may lead to depressed consciousness and mental disorders.

When used concomitantly with indirect anticoagulants (including warfarin), metronidazole increases their effect, which leads to prolongation of the prothrombin time.

The use of metronidazole in combination with nondepolarizing myorelaxants (vecuronium bromide) is not recommended.

Barbiturates may decrease the effectiveness of metronidazole due to its accelerated metabolism in the liver.

Cimetidine inhibits metabolism of metronidazole, which may increase its plasma concentrations and increase the risk of adverse reactions.

Concomitant use with lithium preparations may increase its plasma concentrations.

Special Instructions

The simultaneous treatment with metronidazole by a sexual partner is recommended, regardless of whether he or she has manifestations of the disease.

At the time of treatment with the drug, it is recommended to refrain from sexual intercourse.

In case of a history of changes in peripheral blood counts and when the drug is used in high doses and/or when treatment is prolonged, it is necessary to monitor the total blood count.

Metronidazole may cause immobilization of treponemes, which leads to false-positive Nelson’s test (TPI) results.

Impact on driving and operating machinery

The possibility of dizziness should be considered when prescribing the drug to patients engaged in potentially hazardous activities (especially drivers of vehicles).

Contraindications

Side effects

Local reactions: itching, burning, pain and irritation in the vagina; thick, white, mucous vaginal discharge (odorless or faintly smelling), frequent urination; after drug withdrawal – development of vaginal candidiasis.

Digestive system disorders: nausea, change in taste, metallic taste in the mouth, dry mouth, decreased appetite, spastic abdominal pain, nausea, vomiting, constipation or diarrhea.

CNS disorders: headache, dizziness.

Hematopoietic system disorders: leukopenia or leukocytosis.

Allergic reactions: urticaria, skin itching, rash.

Others: rarely, red-brown coloring of urine due to the presence of water-soluble pigment formed as a result of metabolism of metronidazole; burning sensation or irritation of the penis in the sexual partner.

Overdose

No data on overdose of Trichopol® were provided.

Pregnancy use

Trichopol is contraindicated for use in the first trimester of pregnancy. Use of the drug in the second and third trimesters is possible only in cases when the estimated benefit to the mother exceeds the potential risk to the fetus.

If it is necessary to use Trichopolol during lactation, breastfeeding should be discontinued.

Similarities