Pharmacological action
Pharmacotherapeutic group: adaptogenic agent.
ATC code: A13A
Pharmacological properties
Pharmacodynamics
Trekresan belongs to the group of adaptogenic drugs. Trecrezan stimulates alpha and gamma interferon production, which determines the spectrum of its biological activity (immunostimulating and adaptogenic), influences the body’s immune status due to activation of cellular and humoral parts of immunity, stimulates phagocytic activity of macrophages. The exact mechanism of action of oxyethylammonium methylphenoxyacetate is not established.
The mentioned immunological effects of the preparation, promote endurance during physical and mental exertion, decrease effect of different toxins, increase resistance of the organism to hypoxia, low and high temperatures and other unfavorable environmental factors.
Pharmacokinetics
According to the available data, oxyethylammonium methylphenoxyacetate is highly bioavailable, rapidly metabolized in the liver, being excreted by the kidneys mainly as glucuronides. It does not cumulate in the body with long-term use.
Pharmacokinetics in special clinical cases
The pharmacokinetics of oxyethylammonium methylphenoxyacetate is not significantly changed in elderly patients, children 12-18 years old, patients with renal and hepatic insufficiency.
Indications
As part of complex therapy:
– in the prevention and treatment of acute respiratory viral infections;
– during periods of high intellectual and heavy physical activity;
– to increase the body’s resistance to various stress influences (hypoxia, overheating, hypothermia) and adverse environmental influences (sharp changes in climatic conditions, adaptation to changes in atmospheric pressure).
Pharmacological effect
Pharmacological action
Pharmacotherapeutic group: adaptogenic agent.
ATX code: A13A
Pharmacological properties
Pharmacodynamics
Trecrezan belongs to the group of adaptogenic drugs. Trecrezan stimulates the production of alpha and gamma interferons, which determines the spectrum of its biological activity (immunostimulating, adaptogenic), affects the immune status of the body due to the activation of cellular and humoral immunity, and stimulates the phagocytic activity of macrophages. The exact mechanism of action of oxyethylammonium methylphenoxyacetate has not been established.
These immunological effects of the drug help increase endurance during physical and mental stress, reduce the effect of various toxins, increase the body’s resistance to hypoxia, low and high temperatures and other unfavorable environmental factors.
Pharmacokinetics
According to available data, hydroxyethylammonium methylphenoxyacetate has high bioavailability, is rapidly metabolized in the liver, and is excreted by the kidneys mainly in the form of glucuronides. Does not accumulate in the body with prolonged use.
Pharmacokinetics in special clinical situations
In elderly people, children 12-18 years old, patients with renal and hepatic insufficiency, the pharmacokinetics of oxyethylammonium methylphenoxyacetate does not change significantly.
Special instructions
Patients with diabetes mellitus should be careful when using Trecrezan.
In the case of an acute respiratory viral infection, if you experience the following symptoms, they usually indicate a more severe condition and require mandatory consultation with a specialist – a family doctor or general practitioner:
1) increase in body temperature above 39 °C (high fever);
2) an increase in temperature is accompanied by severe pain, shortness of breath, impaired consciousness, and convulsions;
3) with symptoms of an acute respiratory disease, body temperature above 38.5 °C is observed for 3 days or more;
4) a temperature above 37.5 °C lasts for 2 weeks or more.
Considering that the pharmacokinetic parameters of hydroxyethylammonium methylphenoxyacetate do not change significantly, there is no need to observe any features and restrictions on the use of the drug in children 12-18 years old, elderly patients, patients with impaired liver function, kidneys, other than those indicated in the instructions.
It is not recommended to exceed the recommended dosage.
Impact on the ability to drive vehicles and machinery
The use of the drug does not affect driving or engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Active ingredient
Hydroxyethylammonium methylphenoxyacetate
Composition
1 tablet contains:
Active substance:
Hydroxyethylammonium methylphenoxyacetate (trecrezan) – 200 mg,
Excipients:
Lactose monohydrate (milk sugar) – 200 mg,
Potato starch – 92.5 mg,
Sodium stearyl fumarate – 5 mg,
Colloidal silicon dioxide (aerosil) – 2.5 mg.
Pregnancy
Use during pregnancy and breastfeeding is contraindicated (due to the lack of data on the effectiveness and safety of use).
Contraindications
Hypersensitivity to any of the components of the drug.
Children under 12 years of age (due to the lack of data on the effectiveness and safety of use).
Hereditary lactose intolerance, lactase deficiency or impaired absorption of glucose and galactose.
With caution
Diabetes mellitus (see section “Special instructions”).
Side Effects
In rare cases, allergic reactions are possible: hypersensitivity reactions, anaphylactic shock, anaphylaxis, Quincke’s edema.
If any of the adverse reactions indicated in the instructions worsen, or you notice any other adverse reactions not listed in the instructions, tell your doctor.
Interaction
No undesirable interactions with other drugs have been described.
Overdose
Symptoms of intoxication due to drug overdose were not noted. In case of overdose, symptomatic therapy is recommended.
Storage conditions
Store in consumer packaging at a temperature not exceeding 25 °C.
Keep out of the reach of children.
Shelf life
2 years.
Do not use after expiration date.
Manufacturer
Pharmproject, Russia
Shelf life | 2 years. Do not use after the expiration date. |
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Conditions of storage | Store in the consumer package at a temperature not exceeding 25 ° C. Store out of the reach of children. |
Manufacturer | Pharmproject, Russia |
Medication form | pills |
Brand | Pharmproject |
Other forms…
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