Travocort, cream 1mg+10 mg/g 15 g

Pharmacodynamics

Isoconazole is a synthetic imidazole derivative. Travocort has a broad antifungal and antibacterial spectrum of action. It acts fungicidal and bactericidal. Inhibits ergosterol synthesis of cell membranes of the fungus, causing its death, blocks the synthesis of bacterial proteins.

It is active against dermatophytes (Trichophyton spp., Microsporum spp., Epidermophyton spp. etc.), mold, yeast and yeast-like fungi (Candida spp, Pityrosporum orbiculare/ovale (Malassezia furfur), Corynebacterium minutissimum – the causative agent of erythrazma and Gram-positive bacteria Staphylococcus spp., Streptococcus spp.

Diflucortolone valerate is a GKS for topical use. It has anti-inflammatory, anti-exudative, anti-allergic and antipruritic effects.

Pharmacokinetics

No pharmacokinetic studies have been performed.

Indications

Pruritus, Dermatosis, Fungus

Dermatoses of combined etiology, sensitive to GCS therapy, infected with fungal/bacterial flora.

Fungal skin lesions, including those secondary infected, accompanied by severe inflammatory or eczema-like symptoms:

• foot and smooth skin mycoses, including those localized in folds, interdigital spaces, the area of the external genitalia (including.
• candidicoses;
• erythrax.

.

Active ingredient

Diflucortolone, Isoconazole

Composition

100 g of cream for external use contains:

The active ingredients:

isoconazole nitrate 1 g,

diflucortolone valerate 100 mg;

Excipients:

Polysorbate 60;

sorbitan stearate;

cetoasteryl alcohol;

p> liquid paraffin;

white petroleum jelly;

dietate;

purified water.

How to take, the dosage

Externally.Travocort is applied in a thin layer to the affected skin and lightly rubbed in twice a day (morning and night).

Once inflammation has subsided, treatment with Travocort should be discontinued and treatment with GCS-free Travogen cream continued. This is important when applied to the external genitalia and inguinal folds.

The maximum duration of treatment is 2 weeks.

Special Instructions

Use for external use only.

Avoid contact with eyes and open wounds. If accidental contact occurs, rinse the eyes thoroughly with warm water.

In patients with rosacea or perioral dermatitis, do not apply to the face.

The effect on the ability to drive and operate machinery

No effect has been found.

Contraindications

• High sensitivity to components of Travocort;
• Tuberculosis, syphilitic, viral (varicella, shingles) skin lesions;
• dermal postvaccinal reactions;
• the first trimester of pregnancy.

With caution:- II and III trimesters of pregnancy.

Side effects

Travocort is usually well tolerated, even when applied to sensitive skin.

In rare cases, skin irritation and allergic reactions may develop.

Given that Travocort contains diflucortolone, if the cream is applied over large areas (more than 10% of the skin surface) for a long time (more than 4 weeks) and/or if an occlusive dressing is used, side effects characteristic of GKS may occur: skin atrophy, telangiectasia, strictures, acne-like dermatitis, perioral dermatitis, hypertrichosis, and systemic side effects (suppression of hypothalamic-pituitary-adrenal system function).

We cannot completely rule out side effects (e.g., decreased adrenal cortical function) in infants whose mothers received prolonged treatment during pregnancy or lactation, or who applied the drug to large body surfaces.

Pregnancy use

As with all topical products containing GCS, Travocort is not recommended during the first trimester of pregnancy.

The use of the drug in the second and third trimesters of pregnancy is possible when the potential benefit to the mother outweighs the possible risk to the fetus.

If it is necessary to use the drug during lactation, a physician should be consulted about stopping breastfeeding.