Travocort, cream 1mg+10 mg/g 15 g

Pharmacodynamics

Isoconazole is a synthetic imidazole derivative. Travocort has a broad antifungal and antibacterial spectrum of action. It acts fungicidal and bactericidal. Inhibits ergosterol synthesis of cell membranes of the fungus, causing its death, blocks the synthesis of bacterial proteins.

It is active against dermatophytes (Trichophyton spp., Microsporum spp., Epidermophyton spp. etc.), mold, yeast and yeast-like fungi (Candida spp, Pityrosporum orbiculare/ovale (Malassezia furfur), Corynebacterium minutissimum – the causative agent of erythrazma and Gram-positive bacteria Staphylococcus spp., Streptococcus spp.

Diflucortolone valerate is a GKS for topical use. It has anti-inflammatory, anti-exudative, anti-allergic and antipruritic effects.

Pharmacokinetics

No pharmacokinetic studies have been performed.

Indications

Dermatoses of combined etiology, sensitive to GCS therapy, infected with fungal/bacterial flora.

Fungal skin infections, incl. Secondarily infected, accompanied by severe inflammatory or eczema-like symptoms:

mycoses of the feet and smooth skin, incl. with localization in folds, interdigital spaces, the area of ​​the external genitalia (including balanoposthitis): microsporia, trichophytosis, rubrophytosis, epidermophytosis;
candidiasis;
erythrasma.

Pharmacological effect

Pharmacodynamics

Isoconazole is a synthetic imidazole derivative. Travocort has a wide antifungal and antibacterial spectrum of action. Acts fungicidal and bactericidal. Suppresses the synthesis of ergosterol in fungal cell membranes, causing its death, and blocks the synthesis of bacterial proteins.

Active against dermatophytes (Trichophyton spp., Microsporum spp., Epidermophyton spp., etc.), molds, yeasts and yeast-like fungi (Candida spp., Pityrosporum orbiculare/ovale (Malassezia furfur), Corynebacterium minutissimum – the causative agent of erythrasma and gram-positive bacteria Staphylococcus spp., Streptococcus spp.

Diflucortolone valerate is a corticosteroid for topical use. It has anti-inflammatory, antiexudative, antiallergic and antipruritic effects.

Pharmacokinetics

Pharmacokinetic studies have not been conducted.

Special instructions

Use for external use only.

Avoid contact of the drug with eyes and open wounds. In case of accidental contact with eyes, rinse them thoroughly with warm water.

In patients with rosacea or perioral dermatitis, do not apply the drug to the facial skin.

Impact on the ability to drive a car and operate machinery

Not identified.

Active ingredient

Diflucortolone, Isoconazole

Composition

100 g of cream for external use contains:

Active ingredients:

isoconazole nitrate 1 g,

diflucortolone valerate 100 mg;

Excipients:

polysorbate 60;

sorbitan stearate;

cetostearyl alcohol;

liquid paraffin;

Vaseline white;

disodium edetate;

purified water.

Pregnancy

Like all topical preparations containing corticosteroids, Travocort is not recommended for use during the first trimester of pregnancy.

The use of the drug in the second and third trimester of pregnancy is possible in cases where the potential benefit to the mother outweighs the possible risk to the fetus.

If it is necessary to use the drug during lactation, you should discuss the issue of stopping breastfeeding with your doctor.

Contraindications

Hypersensitivity to the components of Travocort;
tuberculous, syphilitic, viral (chickenpox, herpes zoster) skin lesions;
skin post-vaccination reactions;
I trimester of pregnancy.

With caution: – II and III trimesters of pregnancy.

Side Effects

Travocort is generally well tolerated, even when applied to sensitive skin.

In rare cases, skin irritation and allergic reactions may occur.

Considering that Travocort contains diflucortolone, when using the cream on large surfaces (more than 10% of the skin surface) for a long time (more than 4 weeks) and/or when using an occlusive dressing, side effects characteristic of GCS may occur: skin atrophy, telangiectasia, stretch marks, acne-like dermatitis, perioral dermatitis, hypertrichosis, as well as systemic side effects (suppression functions of the hypothalamic-pituitary-adrenal system).

The development of side effects (for example, decreased function of the adrenal cortex) cannot be completely excluded in newborns whose mothers received long-term treatment during pregnancy or lactation or applied the drug to large surfaces of the body.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

5 years

Manufacturer

LEO Pharma Manufacturing Italy S.r.l., Italy