Toff Plus, capsules 10 pcs

A combined drug for the elimination of symptoms of acute respiratory infections and colds.

Paracetamol has antipyretic and analgesic effect.

Phenylephrine is an alpha-adrenomimetic which has a vasoconstrictor effect, helps relieve nasal congestion and reduces nasal secretion.

Chlorphenamine is a blocker of H1-histamine receptors; it has anti-allergic action, suppresses symptoms of allergic rhinitis (decreases vascular permeability and removes edema and hyperemia of the nasal cavity mucosa).

Dextromethorphan is an anti-cough remedy, by its force of action it is close to codeine, increases the sensitivity threshold of the cough center of the medulla oblongata, suppresses cough of any origin, eliminates the irritating effect of dry unproductive cough and is well tolerated by all age groups.

It has some sedative effect. Does not have analgesic, narcotic and sleeping pills. Does not suppress respiratory center and activity of ciliary epithelium.

The beginning of action is within 20-30 minutes and its duration is 4-4.5 hours.

Indications

infectious and inflammatory (cold) diseases (including ARVI, influenza, rhinitis, nasopharyngitis);
allergic rhinitis;
rhinorrhea.

Pharmacological effect

A combined drug to eliminate the symptoms of acute respiratory infections and colds.

Paracetamol has antipyretic and analgesic effects.

Phenylephrine is an alpha-addermimetic, has a vasoconstrictor effect, helps eliminate nasal congestion, and reduce mucous secretions from the nasal cavity.

Chlorphenamine is a blocker of H1-histamine receptors, has an antiallergic effect, suppresses the symptoms of allergic rhinitis (reduces vascular permeability, eliminates swelling and hyperemia of the nasal mucosa).

Dextromethorphan is an antitussive agent, similar in strength to codeine, increases the sensitivity threshold of the cough center of the medulla oblongata, suppresses cough of any origin, eliminates the irritating effect of dry non-productive cough and is well tolerated by all age groups.

Has some sedative effect. Does not have analgesic, narcotic or hypnotic effects. Does not inhibit the respiratory center and the activity of the ciliated epithelium.

The onset of action is 20-30 minutes, duration is 4-4.5 hours.

Special instructions

During the treatment period, you should not take other drugs containing substances included in the drug.

In persons suffering from chronic alcoholism, taking therapeutic doses of the drug can cause severe liver failure.

During the treatment period, it is necessary to refrain from drinking ethanol (hepatotoxicity may develop).

Impact on the ability to drive vehicles and operate machinery

During the treatment period, it is necessary to refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Dextromethorphan, Paracetamol, Phenylephrine, Chlorphenamine

Composition

1 capsule contains:

Capsules1 capsule

paracetamol 500 mg

dextromethorphan hydrobromide 15 mg

phenylephrine hydrochloride10 mg

chlorphenamine maleate2 mg

Excipients

Croscarmellose sodium 10.00 mg,

povidone (K-30) 20.00 mg,

gelatin 5.00 mg,

talc 10.00 mg,

sodium disulfite 0.50 mg,

microcrystalline cellulose 18.64 mg

sucrose 52.00 mg,

cellulose acetate phthalate 4.50 mg,

diethyl phthalate 0.60 mg,

quinoline yellow dye 0.13 mg,

brilliant blue dye 0.13 mg,

crimson dye (Ponceau 4R) 1.50 mg.

Shell composition

Water, gelatin, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium lauryl sulfate, brilliant blue dye.

Pregnancy

Contraindication: pregnancy; lactation period.

Use in children

Contraindication: children (under 14 years of age).

Contraindications

hypersensitivity;
simultaneous use of other drugs containing substances included in Toff Plus;
simultaneous use of tricyclic antidepressants, MAO inhibitors, beta-blockers;
deficiency of glucose-6-phosphate dehydrogenase;
blood diseases;
liver and/or kidney failure;
angle-closure glaucoma;
prostate adenoma;
Gilbert’s syndrome;
arterial hypertension;
thyrotoxicosis; pheochromocytoma; diabetes mellitus;
bronchial asthma, bronchitis;
lactation period;
children’s age (up to 14 years).

With caution:

angina pectoris;
hypertrophic obstructive cardiomyopathy (HOCM);
old age.

Side Effects

From the nervous system and sensory organs: dizziness, drowsiness, increased excitability, mydriasis, accommodation paresis, increased intraocular pressure.

From the digestive system: dry mouth, epigastric pain, nausea, vomiting, hepatotoxic effect.

From the hematopoietic organs: anemia, thrombocytopenia, hemolytic anemia, aplastic anemia.

From the urinary system: urinary retention, nephrotoxicity (papillary necrosis).

Allergic reactions: skin rash, itching, angioedema, bronchial obstruction.

Other: increased blood pressure.

Interaction

Enhances the effects of MAO inhibitors, sedatives, ethanol.

Antidepressants, antiparkinsonian drugs, antipsychotic drugs, phenothiazine derivatives increase the risk of developing urinary retention, dry mouth, and constipation.

Glucocorticosteroids increase the risk of developing glaucoma.

Paracetamol reduces the effectiveness of uricosuric drugs.

Chlorpheniramine, prescribed simultaneously with MAO inhibitors and furazolidone, can lead to the development of a hypertensive crisis, psychomotor agitation, and fever.

Tricyclic antidepressants enhance the sympathomimetic effect; simultaneous administration of halothane increases the risk of developing ventricular arrhythmia.

Reduces the hypotensive effect of guanethidine, which, in turn, enhances the alpha-adrenergic stimulating activity of phenylephrine.

Overdose

Symptoms (caused by paracetamol, appear after taking more than 10-15 g): pallor of the skin, anorexia, nausea, vomiting, hepatonecrosis, increased activity of liver transaminases, increased prothrombin time.

Treatment: gastric lavage followed by the administration of activated charcoal, symptomatic therapy.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 °C.

Shelf life

3 years.

Manufacturer

Panacea Biotech, India