Tobrazon, eye drops 5 ml

A combined drug with the properties of its active ingredients – an antibiotic and a glucocorticosteroid.

Tobramycin is an antibacterial drug from the group of aminoglycosides (2nd generation). It suppresses the growth and development of gram-negative and gram-positive microorganisms. It blocks 30 – S subunit in ribosomes and stops protein synthesis. In higher concentrations it disrupts cytoplasmic membrane function, causing cell death.

The drug is active against Gram-positive bacteria (Staphylococcus aureus –

Staphylococcus aureus, Staphylococcus epidermidis, Citrobacter Species, Enterobacter Species) and Gram-negative bacteria (Escherichia coli, Klebsiella Species, Morganella Morganii, Pseudomonas aeruginosa, Proteus mirabili, Proteus vulgaris, Providensia spp, Serratia spp).

Dexamethasone is a fluorinated glucocorticosteroid with pronounced anti-inflammatory, anti-allergic and immunosuppressive effects.

When applied topically, it relieves itching and narrows blood vessels.

It interacts with specific cytoplasmic receptors and forms a complex that penetrates the cell nucleus and stimulates mRNA synthesis. Prevents the release of inflammatory mediators from eosinophils and mast cells. Inhibits the activity of hyaluronidase, collagenase and proteases. Reduces capillary permeability and stabilizes cell membranes.

Pharmacokinetics:

In local administration systemic absorption is low.

Indications

Tobrazon is indicated for the treatment of infectious diseases of the eye and para-orbital area caused by microorganisms sensitive to the drug:

blepharitis, conjunctivitis, blepharoconjunctivitis;

keratitis (without epithelial damage);

Active ingredient

Composition

Active ingredients:

Tobramycin sulfate, tobramycin equivalent, 3.0 mg

Dexamethasone sodium phosphate, dexamethasone equivalent, 1.0 mg

Excipients:

Benzalkonium chloride, EDTA disodium, disodium hydrophosphate dihydrate, sodium metabisulfite, sodium chloride, creatine, propylene glycol, purified water, sodium hydroxide *) sulfuric acid *).

How to take, the dosage

Interaction

Special Instructions

Wearing of soft contact lenses is prohibited during treatment with the drug. If rigid lenses are used, they should be removed before injection and put back on 15-20 minutes after instillation of the drug.

Patients who temporarily lose vision after application are not recommended to drive or operate machinery, machines or other complex equipment which require clarity of vision immediately after application.

The bottle should be closed after each use. Do not touch the pipette tip to the eye.

Contraindications

Individual hypersensitivity to the components of the drug.

Viral diseases of the cornea and conjunctiva (including. keratitis caused by Herpes simplex, varicella);

culosis of the eye;

fungal diseases of the eye;

Side effects

Local allergic reactions: swelling, itching of the eyelids, conjunctival erythema.

Overdose

The symptoms of overdose are similar to the adverse reactions (pitting keratitis, erythema, increased lacrimation, edema and itching of the eyelids).

The treatment is symptomatic with subsequent withdrawal of the drug.

Pregnancy use

Similarities