ATX:
L.03.A.X Other immunostimulants
Pharmacodynamics:
A low molecular weight synthetic interferon inducer that stimulates formation of interferon alpha, beta and gamma in the body. The main producers of interferon in response to tiloron administration are intestinal epithelial cells, hepatocytes, T lymphocytes, neutrophils and granulocytes. After oral administration, the maximum production of interferon is determined in the sequence intestine – liver – blood in 4-24 hours. Amixin® has an immunomodulatory and antiviral effect.
In human leukocytes it induces synthesis of interferon. It stimulates bone marrow stem cells and, depending on the dose, enhances antibody formation, reduces the degree of immunosuppression, restores the ratio of T-suppressors and T-helpers. Effective against various viral infections, including influenza viruses, other acute respiratory viral infections, hepatitis viruses and herpesviruses. The mechanism of antiviral action is associated with inhibition of translation of virus specific proteins in infected cells resulting in suppression of virus reproduction.
Pharmacokinetics:
After oral administration, it is rapidly absorbed from the gastrointestinal tract. Bioavailability is 60%. About 80% of the drug is bound to plasma proteins. The drug is excreted practically unchanged in intestine (70%) and kidney (9%). The elimination half-life (T1/2) is 48 hours. The drug is not biotransformed and does not accumulate in the body.
Indications
treatment and prevention of influenza and other acute respiratory viral infections;
treatment of viral hepatitis A, B and C, herpes and cytomegalovirus infections;
as part of complex therapy of infectious-allergic and viral encephalomyelitis (multiple sclerosis, leukoencephalitis, uveoencephalitis, etc.);
as part of complex therapy of urogenital and respiratory chlamydia;
in complex therapy of pulmonary tuberculosis.
Pharmacological effect
ATX:
L.03.A.X Other immunostimulants
Pharmacodynamics:
A low-molecular-weight synthetic interferon inducer that stimulates the formation of alpha, beta and gamma interferons in the body. The main producers of interferon in response to the administration of tilorone are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After oral administration, the maximum production of interferon is determined in the sequence intestine – liver – blood after 4-24 hours. Amiksin® has an immunomodulatory and antiviral effect.
Induces the synthesis of interferon in human leukocytes. Stimulates bone marrow stem cells, depending on the dose, enhances antibody formation, reduces the degree of immunosuppression, restores the ratio of T-suppressors and T-helpers. Effective against various viral infections, including influenza viruses, other acute respiratory viral infections, hepatitis viruses and herpes viruses. The mechanism of antiviral action is associated with inhibition of the translation of virus-specific proteins in infected cells, as a result of which viral reproduction is suppressed.
Pharmacokinetics:
After oral administration, it is quickly absorbed from the gastrointestinal tract. Bioavailability – 60%. About 80% of the drug binds to plasma proteins. The drug is excreted almost unchanged through the intestines (70%) and through the kidneys (9%). The half-life (T1/2) is 48 hours. The drug does not undergo biotransformation and does not accumulate in the body.
Special instructions
It is not recommended to use tilorone in doses exceeding the recommended ones in order to avoid possible short-term depletion of immunocompetent cells.
As part of complex therapy for neuroviral infections, tilorone is used under medical supervision.
Active ingredient
Tiloron
Composition
Composition per tablet
Active ingredient
Tiloron (Tilaxin®) – 125,000 mg.
Excipients
Magnesium hydroxycarbonate (basic magnesium carbonate) – 49,000 mg, talc – 4,000 mg, povidone (low molecular weight medical polyvinylpyrrolidone) – 20,000 mg, calcium stearate – 2,000 mg.
Shell composition
Sucrose (sugar) – 108.634 mg, magnesium hydroxycarbonate (main magnesium carbonate) – 72.974 mg, povidone (low molecular weight medical polyvinylpyrrolidone) – 4.441 mg, talc – 0.741 mg, colloidal silicon dioxide (aerosil) – 1.266 mg, titanium dioxide (titanium dioxide pigment) – 1.266 mg, tropeolin O – 0.028 mg, liquid paraffin (vaseline oil) – 0.004 mg, medical gelatin – 0.637 mg, beeswax – 0.009 mg.
Contraindications
Pregnancy, lactation (breastfeeding), children under 7 years of age, hypersensitivity to tilorone.
Side Effects
Possible: short-term chills, allergic reactions.
In some cases: dyspeptic symptoms.
Interaction
Tiloron is compatible with antibiotics and traditional treatments for viral and bacterial diseases.
Manufacturer
Dalkhimfarm, Russia
Manufacturer | Dalkhimpharm, Russia |
---|---|
Medication form | pills |
Brand | Dalkhimpharm |
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