Tick-borne encephalitis vaccine, 1 dose, 5 pcs.
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The vaccine stimulates the production of cellular and humoral immunity to tick-borne encephalitis virus.
After two injections of the drug (vaccination course) viral neutralizing antibodies are detected in at least 90% of those vaccinated.
Indications
Specific prevention of tick-borne encephalitis for children from 3 years old and adults, immunization of donors to obtain specific immunoglobulin.
The contingents to be vaccinated:
The population living in areas enzootic for tick-borne encephalitis, as well as persons arriving in these areas who perform the following work:
Active ingredient
Composition
One inoculation dose (0.5 ml) of the drug contains:
specific antigen of tick-borne encephalitis virus – active ingredient ;
Human donor albumin – 250+50 mcg (stabilizer);
sucrose – 37,5+0,5 mg (stabilizer);
gelatin – 5+0,5 mg (shaper);
Bovine serum albumin – not more than 0.5 mg;
protamine sulfate – not more than 5 mg.
The vaccine contains no formaldehyde, antibiotics and preservatives.
How to take, the dosage
1. Preventive vaccination.
The vaccination course consists of two intramuscular injections of 1 dose (0.5 ml) at intervals of 1-7 months. The vaccination course (two injections) can be carried out throughout the year, including the summer period (epidemic season), but not later than two weeks before visiting a tick-borne encephalitis center.
The interval between the first and second vaccinations of 5-7 months (autumn – spring) is the most optimal. Revaccination is carried out once in a dose of 0.5 ml in 1 year after the completion of the vaccination course. Follow-up booster vaccinations are carried out once every three years.
Vaccination is carried out in strict compliance with the rules of asepsis and antisepsis. The vaccine is dissolved in the supplied solvent at the rate of 0.5 ml per dose. Ampoule with solvent is shaken vigorously, neck of the ampoule is treated with alcohol, opened, the solvent is collected into a syringe and injected into the ampoule with dry vaccine. The contents of the ampoule with the vaccine are stirred intensively for 3 – x minutes until the vaccine is completely dissolved, filling it several times in the syringe without foaming.
The vaccine should form a homogeneous suspension within 3 minutes when the vaccine solvent (0.5 ml for 1 dose and 1.0 ml for 2 doses) is added to the ampoule. Before each injection, the contents of the ampoule is stirred, since during settling the suspension separates into colorless transparent supernatant and loose white sediment, the inoculation is performed immediately after the vaccine dose has been added to the syringe. Dissolved in an ampoule vaccine should not be stored.
The drug is not suitable in ampoules with compromised integrity, labeling, with the detection of foreign inclusions, with changes in physical properties (severe deformation of the tablet – porous mass of white color becomes translucent and melted in shape, color changes, the presence of large unbreakable conglomerates in the solvent after shaking it), with expired shelf life, with violation of the temperature conditions of storage or transportation.
The drug is administered intramuscularly in the deltoid muscle of the shoulder
The vaccinations performed shall be recorded in the established record forms indicating the name of the drug, date of vaccination, dose, series number, reaction to vaccination.
2. Donor vaccination.
The course of vaccination is two 0.5 ml injections 5-7 months apart or three 0.5 ml injections for the first, and 1.0 ml for the second and third, with an interval of 3-5 weeks between shots. The first schedule provides the best immunizing effect. Revaccination is by a dose of 0.5 ml after 6-12 months. The method of administration is similar to that for prophylactic vaccination. The first blood sampling from donors is carried out 14-30 days after the vaccination course.
Special Instructions
In some cases local and general reactions may occur after the vaccine has been administered. Local reactions are expressed as redness, swelling, painfulness at the injection site, development of infiltrates. There may be a slight increase in regional lymph nodes. The duration of local reactions does not exceed 3 days.
General reactions may develop within the first two days after vaccination and are manifested as fever, headache, malaise, their duration does not exceed 48 hours. The frequency of reactions with a temperature of more than 37.5 ° C should not exceed 7%.
In extremely rare cases, vaccinations can be accompanied by the development of immediate allergic reactions, in connection with which the vaccinated must be under medical supervision for 30 minutes after vaccination. Vaccination sites must be provided with anti-shock and anti-allergic therapy.
Contraindications
The contraindications listed above, as well as those related to donor selection, should be considered when vaccinating donors.
In each case of a disease not contained in this list of contraindications, the vaccination shall be carried out with the permission of a physician, based on the health status of the vaccinated person and the risk of tick-borne encephalitis. In order to identify contraindications, the doctor (paramedic) conducts an interview and examination of the vaccinated person on the day of vaccination with mandatory thermometry.
The vaccination against tick-borne encephalitis is carried out not earlier than 1 month after the vaccination against another infectious disease. Vaccination against tick-borne encephalitis is allowed simultaneously (on the same day) with other vaccinations with inactivated vaccines (except anti-rabies) of the National calendar of preventive vaccinations and calendar of preventive vaccinations for epidemic indications.
Weight | 0.042 kg |
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Shelf life | 3 years. |
Conditions of storage | The drug is stored and transported in accordance with SP 3.3.2. 1248-03 at 2 to 8 ° C. Do not freeze. Allowed for transportation at temperatures from 9 to 25 ° C for 2 days. For long distances – only by air transport. |
Manufacturer | FSUE Chumakov Institute, Russia |
Medication form | solution for injection |
Brand | FSUE Chumakov Institute |
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