Thiapride, tablets 100 mg 20 pcs

Pharmacotherapeutic group

Antipsychotic medicine (neuroleptic)

ATX code

N05AL03

Pharmacodynamics: Antipsychotic drug (neuroleptic); has sedative sedative analgesic effect. It eliminates dyskinesia of central origin. It has a pronounced analgesic effect both for interoceptive and exteroceptive pain. Antipsychotic effect is caused by blockade of dopamine 02-receptors of mesolimbic and mesocortical system. Sedative action is caused by blockade of adrenoreceptors of reticular formation of brain stem; antiemetic action – by blockade of dopamine 02-receptors of trigger zone of vomiting center; hypothermic action – by blockade of dopamine receptors of hypothalamus.
Pharmacokinetics: After oral administration of 200 mg tiapride, the maximum concentration of the drug in plasma !3 mcg/ml is reached in 1 hour.

The bioavailability of the tablets is 75%. When taken immediately before meals the bioavailability is increased by 20% and the maximum concentration in plasma by 40%. Absorption in the elderly slows down.

Distribution in the body is fast (less than 1 hour). It penetrates through the blood-brain barrier and there is no cumulation through the placenta. The drug penetration into milk was noted in animals with the ratio of concentrations in milk to blood 1:2.

Binding with plasma proteins and erythrocytes is weak. Thiapride metabolism is very low: 70% of the dose is found unchanged in urine. The plasma elimination half-life is 29 hours in women and 36 hours in men. Excretion occurs mainly with urine and renal clearance reaches 330 ml/minute.

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