Theopec, 100 mg 50 pcs.

Theophylline refers to phosphodiesterase inhibitors. It increases accumulation of c-AMP in tissues, which reduces the contractile activity of smooth muscles.

Theophylline dilates bronchi, blood vessels (mainly brain, skin and kidney vessels). It reduces pulmonary vascular resistance, lowers the pressure in the small circle of the circulation. Increases renal blood flow. It has a moderately pronounced diuretic effect. Inhibits platelet aggregation.

It has a stimulating effect on the respiratory center, increases the frequency and strength of heart contractions. Delayed release of the active substance from the tablet ensures that the therapeutic level of theophylline in the blood reaches 3-5 hours after taking Theopec and lasts for 10-12 hours.

Twice administration of the drug allows obtaining effective concentrations of theophylline in blood within 24 hours. Because of the long-term action of the drug, one of the important indications for use is to prevent nocturnal and pre-morning bronchospasm phenomena.

Pharmacokinetics:

Theophylline is completely absorbed after oral administration (90% bioavailability). In the blood 40-60% bound to proteins. It penetrates through histohematic barriers.

It is bioreformed in liver with formation of inactive metabolites. It is excreted from the body mainly by the kidneys, partially with breast milk.

Indications

Bronchial asthma, asthmatic status, obstructive bronchitis, pulmonary emphysema, apnea in newborns (adjuvant).

Active ingredient

Composition

Theophylline 100 mg.

Auxiliary substances:

composite polymeric carrier (polymethacrylic acid and macrogol (polyethylene glycol) interpolymer complex),

calcium stearate.

How to take, the dosage

Theopec is used orally after meals with water. The tablet is not crushed, chewed or dissolved in water.
The daily dose is divided into two doses 12 hours apart. The optimal dose is chosen individually depending on the nature of the disease, age and weight of the patient.

The preparation is given twice a day to adults and children over 14 years old – 300 mg; to children from 7 to 12 years old – 200 mg, to children from 3 to 7 years old – 100 mg.

The first day of treatment starts with half of the daily dose in 2 doses.

In the absence of adverse reactions we switch to the full daily dose.
The duration of the drug administration depends on the course of the disease and the therapeutic effect.
On average the course of treatment can last from two weeks to two months.

Interaction

Theophylline is not used together with other xanthine derivatives.

In combination with phenobarbital, diphenin, rifampicin, isoniazid, carbamazepine, sulfinpyrazone, phenytoin a decrease in the effectiveness of theophylline is observed, which may require increasing the used doses of the drug.

In concomitant use with antibiotics of the macrolide group, lincomycin, allopurinol, cimetidine, isoprenaline, beta-adrenoblockers, oral contraceptives, epoxacin and during vaccination against influenza the intensity of action may increase, which may require reduction of theophylline dose.

Theophylline increases the likelihood of side effects of glucocorticosteroids, mineralocorticosteroids (hypernatremia), drugs that excite the central nervous system (increases neurotoxicity).

The drug suppresses the therapeutic effects of lithium carbonate and beta-adrenoblockers.

Theophylline potentiates the effects of diuretics by increasing glomerular filtration and decreasing tubular reabsorption.

Theophylline is used with caution concomitantly with anticoagulants.

Antidiarrheals and enterosorbents decrease absorption of theophylline.

Special Instructions

In expressed coronary insufficiency (angina pectoris, myocardial infarction in the acute period), ventricular extrasystole, total vascular atherosclerosis, obstructive hypertrophic cardiomyopathy, peptic ulcer disease, chronic heart failure, Expressed pathology of the liver system, increased seizure activity, prostatic hypertrophy, gastroesophageal reflux, pregnancy, thyrotoxicosis, uncontrolled hypothyroidism (cumulation is recorded), the drug is used with caution.

In pediatric practice and elderly patients, Theopec may be prescribed for vital indications.

The rectal forms are used with caution in diagnosed diseases of the rectum (and with suspicion of them), with diarrheal syndrome. In smoking patients there is a decrease in the effectiveness of the drug.

Continuous therapy with other drugs in which the active ingredient is xanthine derivatives is unacceptable. In elderly patients with significant concomitant pathology, with viral infectious lesions, with diseases of the hepatic and cardiovascular systems, correction of the scheme of treatment is required.

Contraindications

Hypersensitivity, including to other xanthine derivatives (caffeine, pentoxifylline, theobromine), hemorrhagic stroke, retinal hemorrhage, acute myocardial infarction, marked coronary atherosclerosis, bleeding in recent history, pregnancy, lactation.

Side effects

Nervous system disorders

Dizziness Headache, Insomnia agitation, anxiety, irritability, tremor.

Cardiovascular system disorders

Heart palpitations, tachycardia (including in the fetus when pregnant in the third trimester), arrhythmias, decreased blood pressure, cardialgia, increased frequency of angina attacks.

Digestive system disorders

Gastralgia, nausea, vomiting, gastroesophageal reflux, heartburn, aggravation of peptic ulcer disease, diarrhea, with prolonged use – loss of appetite.

Allergic reactions

Skin rash, itching, fever.

Other

Breast pain, tachypnoea, sensation of flushing of the face, albuminuria, hematuria, hypoglycemia, increased diuresis, increased sweating.

The side effects decrease with lowering the dose of the drug.

Overdose