Teturam, tablets 150 mg 30 pcs

Teturam inhibits acetaldehyde dehydrogenase involved in ethanol metabolism; it increases the concentration of acetaldehyde which is a metabolite of ethanol and causes a number of unpleasant feelings after its use (“rushes” of blood to the skin, nausea, vomiting, malaise, tachycardia, BP lowering).

As a result, the development of conditioned reflex reaction of aversion to the taste and smell of ethanol takes place.

The duration of action of oral tablets is 48 hours. The use in the form of implants creates a constant concentration of the drug in the body. Disulfiram-ethanol” reactions may occur within 5-9 months after implantation.

In case of ethanol ingestion, lipid mobilization occurs, vasodilation and increased blood flow at the implantation site, resulting in an increased flow of disulfiram into the blood.

Indications

Treatment and prevention of relapse of chronic alcoholism; as a detoxifying agent in chronic nickel poisoning.

Active ingredient

Composition

Active ingredient:

teturam 150 mg;

Associates:

Potato starch,

Stearic acid,

Aerosil.

How to take, the dosage

The treatment is prescribed after careful examination of the patient and warning about the effects and complications. The drug is taken orally not more than 500 mg once a day according to an individual scheme.

In 7-10 days we conduct tetramalcohol test (20-30 ml of 40% vodka after taking 500 mg of the preparation), in case of weak reaction the alcohol dose is increased by 10-20 ml (maximum dose of vodka is 100-120 ml).

The test is repeated in 1-2 days in the hospital and in 3-5 days on an outpatient basis, with correction of the doses of alcohol and/or the drug as necessary. Thereafter, a maintenance dose of 150-200 mg per day may be used for 1-3 years.

Interaction

Contraindicated combinations

Alcohol: intolerance reaction (hot flashes, erythema, vomiting, tachycardia). Avoid taking alcoholic beverages and medicines containing alcohol.

Indesirable combinations

Isoniazid: behavioral and coordination disorders.

Nitro-5-imidazoles (metronidazole, ordinazole, secnidazole, tinidazole): delirium disorders, confusion.

Phenytoin.: significant and rapid rise in plasma levels of phenytoin with toxic symptoms (suppression of its metabolism).

If the combination cannot be avoided, clinical observation and monitoring of plasma concentrations of the drug in and after treatment with teturam should be performed.

Combinations requiring caution

Warfarin (and other oral anticoagulants): increased effect of oral anticoagulants and risk of bleeding (reduced breakdown of warfarin in the liver). More frequent monitoring of warfarin concentrations and adjustment of anticoagulant dose within 8 days of Tetum withdrawal is recommended.

Theophylline: Teturam inhibits theophylline metabolism. As a result, the dose of theophylline should be adjusted (reduced dosage), depending on clinical symptoms and plasma concentrations of the drug.

Benzodiazepines: teturam may potentiate the sedative effect of benzodiazepines by inhibiting their oxidative metabolism (especially chlordiazepoxide and diazepam). Benzodiazepine dosage should be adjusted according to clinical manifestations.

Tricyclic antidepressants: possible exacerbation of alcohol intolerance reactions (especially if patients take alcoholic beverages while taking Teturam).

Special Instructions

Patients should be warned about the risk of alcohol intolerance reactions.

Teturam should be taken with caution in patients with renal insufficiency or hypothyroidism, especially at the risk of possible combination with alcohol.

Contraindications

Absolute:

Relative:

Side effects

Bitter taste in the mouth, headache, dizziness, memory impairment, insomnia, and anxiety may occur during treatment with Teturam.

The most common side effects of Teturam are allergic reactions – hives, skin rash, Quincke’s edema, bronchospasm, dermatitis.

Teturam tablets may cause rejection when implanted, manifesting as collapse, arrhythmia, cerebral edema, suppuration, heart attack.

Overdose

Symptoms: the teturam-ethanol combination may cause depression of consciousness up to coma, cardiovascular collapse, neurological complications.

Treatment: symptomatic.

Similarities