Teturam, tablets 150 mg 30 pcs

How to take, the dosage

The treatment is prescribed after careful examination of the patient and warning about the effects and complications. The drug is taken orally not more than 500 mg once a day according to an individual scheme.

In 7-10 days we conduct tetramalcohol test (20-30 ml of 40% vodka after taking 500 mg of the preparation), in case of weak reaction the alcohol dose is increased by 10-20 ml (maximum dose of vodka is 100-120 ml).

The test is repeated in 1-2 days in the hospital and in 3-5 days on an outpatient basis, with correction of the doses of alcohol and/or the drug as necessary. Thereafter, a maintenance dose of 150-200 mg per day may be used for 1-3 years.

Interaction

Contraindicated combinations

Alcohol: intolerance reaction (hot flashes, erythema, vomiting, tachycardia). Avoid taking alcoholic beverages and medicines containing alcohol.

Indesirable combinations

Isoniazid: behavioral and coordination disorders.

Nitro-5-imidazoles (metronidazole, ordinazole, secnidazole, tinidazole): delirium disorders, confusion.

Phenytoin.: significant and rapid rise in plasma levels of phenytoin with toxic symptoms (suppression of its metabolism).

If the combination cannot be avoided, clinical observation and monitoring of plasma concentrations of the drug in and after treatment with teturam should be performed.

Combinations requiring caution

Warfarin (and other oral anticoagulants): increased effect of oral anticoagulants and risk of bleeding (reduced breakdown of warfarin in the liver). More frequent monitoring of warfarin concentrations and adjustment of anticoagulant dose within 8 days of Tetum withdrawal is recommended.

Theophylline: Teturam inhibits theophylline metabolism. As a result, the dose of theophylline should be adjusted (reduced dosage), depending on clinical symptoms and plasma concentrations of the drug.

Benzodiazepines: teturam may potentiate the sedative effect of benzodiazepines by inhibiting their oxidative metabolism (especially chlordiazepoxide and diazepam). Benzodiazepine dosage should be adjusted according to clinical manifestations.

Tricyclic antidepressants: possible exacerbation of alcohol intolerance reactions (especially if patients take alcoholic beverages while taking Teturam).

Special Instructions

Patients should be warned about the risk of alcohol intolerance reactions.

Teturam should be taken with caution in patients with renal insufficiency or hypothyroidism, especially at the risk of possible combination with alcohol.

Contraindications

Absolute:

• Serious diseases of the cardiovascular system.
• Hearing organs (neuritis of the auditory nerve).
• Sight organ (glaucoma, optic neuritis).
• Bronchial asthma.
• Emphysema of the lungs.
• Pulmonary tuberculosis.
• Severe liver failure.
• Diseases of hematopoietic organs.
• Diabetes mellitus.
• Thyrotoxicosis.
• Epilepsy.
• Convulsive syndrome of any genesis.
• Mental disorders.
• Exacerbation of peptic ulcer.
• Kidney disease.
• Cancerous tumors.
• Polineuritis of any etiology.
• Pregnancy.
• High individual sensitivity to the drug.

Relative:

• Cardiovascular disease in compensation.
• Elderly age (over 60 years).
• Gastric and duodenal ulcer in remission.
• Residual phenomena after NIC.
• Previously suffered teturaum (antabuse) psychosis.

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Side effects

Bitter taste in the mouth, headache, dizziness, memory impairment, insomnia, and anxiety may occur during treatment with Teturam.

The most common side effects of Teturam are allergic reactions – hives, skin rash, Quincke’s edema, bronchospasm, dermatitis.

Teturam tablets may cause rejection when implanted, manifesting as collapse, arrhythmia, cerebral edema, suppuration, heart attack.

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Overdose

Symptoms: the teturam-ethanol combination may cause depression of consciousness up to coma, cardiovascular collapse, neurological complications.

Treatment: symptomatic.

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Similarities

Esperal