Terbinafin-MFF, tablets 250 mg 10 pcs

Antifungal agent of allilamines group. It acts by inhibiting squalene epoxidase in the cell membrane of the fungus. This leads to ergosterol deficiency and to intracellular accumulation of squalene, which causes cell death of the pathogen.

It has a fungicidal effect on dermatophytes, mold and some dimorphic fungi, yeast and yeast-like fungi. It may act fungistatically on some yeast fungi.

It is active against the causative agents of dermatomycosis (Trichophyton /including. Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton verrucosum, Trichophyton violaceum/, also Microsporum canis and Epidermophyton floccosum); yeast-like fungi of the Candida family (mainly Candida albicans); causative agent of lichen (Malassezia furfur).

Indications

For oral administration: fungal skin infections caused by dermatophytes – trichophytosis, epidermophytosis, microsporia, fungal infections of the nails (onychomycosis), candidiasis.

For external use: fungal skin lesions caused by dermatophytes, candidiasis; lichen versicolor.

Pharmacological effect

Antifungal agent of the allylamine group. It acts by inhibiting squalene epoxidase in the cell membrane of the fungus. This leads to ergosterol deficiency and intracellular accumulation of squalene, which causes the death of the pathogen cell.

It has a fungicidal effect on dermatophytes, molds and some dimorphic fungi, yeast and yeast-like fungi. It can act fungistatically on some types of yeast fungi.

Active against pathogens of dermatomycosis (Trichophyton /including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton verrucosum, Trichophyton violaceum/, also Microsporum canis and Epidermophyton floccosum); yeast-like fungi of the genus Candida (mainly Candida albicans); the causative agent of pityriasis versicolor (Malassezia furfur).

Special instructions

Terbinafine should be used orally with caution in patients with impaired liver and/or kidney function, as well as in the elderly.

Active ingredient

Terbinafine

Composition

1 tab. contains:

Contraindications

Hypersensitivity to terbinafine.

Side Effects

From the digestive system: nausea, anorexia, moderate abdominal pain, diarrhea, disturbances or loss of taste, cholestasis, jaundice, hepatitis.

Allergic reactions: skin rash; rarely – arthralgia, myalgia, erythema multiforme, Stevens-Johnson syndrome.

From the side of the central nervous system: headache.

From the hematopoietic system: neutropenia, thrombocytopenia.

Local reactions: hyperemia, itching, burning sensation.

Interaction

Drugs that cause the induction of microsomal liver enzymes increase the clearance of terbinafine; drugs that inhibit microsomal liver enzymes reduce the clearance of terbinafine.

Manufacturer

Moscow pharmaceutical factory, Russia