TeraFlu for flu and cold, 14 pcs.

A combination drug, the effect of which is due to its constituent components. It has antipyretic, analgesic, vasoconstrictor effect, eliminates the symptoms of “colds”. Narrows vessels and eliminates edema of the mucous membranes of the nasal cavity and nasopharynx.

Paracetamol has analgesic and antipyretic effect by inhibiting the synthesis of prostaglandins in the CNS. It does not affect platelet function and hemostasis.

Pheniramine is an anti-allergic agent, a blocker of histamine H1-receptors. It eliminates allergic symptoms, has a moderate sedative effect and antimuscarinic activity.

Phenylephrine is an alpha1-adrenomimetic, causes vasoconstriction, eliminates swelling and hyperemia of the nasal mucosa.”

Indications

Anesthesia, Gum inflammation, Pain, Angina, stuffy nose, sore throat, inflammation in the mouth, laryngitis, headache, chills, runny nose (rhinitis) Symptomatic treatment of infectious and inflammatory diseases (SARS, including flu), accompanied by fever, chills, body aches, headache and muscle pain, runny nose, stuffy nose, sneezing.

Active ingredient

Paracetamol, Phenylephrine, Pheniramine, Ascorbic acid

Composition

Paracetamol;

Pheniramine maleate;

Phenylephrine hydrochloride;

Ascorbic acid.

How to take, the dosage

Inside. The contents of one sachet dissolved in one cup of hot, but not boiling water. Take in hot water. The second dose may be taken every 4-6 hours (no more than 3-4 doses within 24 hours).

TeraFlu® for flu and colds can be used at any time of the day, but the best effect is achieved by taking the drug before going to bed at night. If the relief of symptoms is not observed within 3 days after the beginning of the preparation it is necessary to consult a physician.

It is not necessary to use TheraFlu® from flu and cold for more than 5 days.

In patients with liver dysfunction or Gilbert syndrome it is necessary to decrease the dose or increase interval between the doses.

In severe renal failure (CK< 10 ml/min) the interval between doses should be at least 8 h.

In elderly patients dosage adjustment is not required.

Interaction

Paracetamol

Increases the effects of MAO inhibitors, sedatives, ethanol.

The risk of hepatotoxic effects of paracetamol increases with the simultaneous use of barbiturates, phenytoin, phenobarbital, carbamazepine, rifampicin, isoniazid, zidovudine and other inducers of microsomal liver enzymes.

Long-term regular use of paracetamol may increase anticoagulant effect of warfarin and other coumarins, with increased risk of bleeding. Single use of paracetamol has no significant effect.

Metoclopramide increases the rate of absorption of paracetamol and reduces the time to reach its Cmax in plasma.

Paracetamol may increase the T1/2 of chloramphenicol.

Paracetamol may decrease the bioavailability of lamotrigine and the efficiency of lamotrigine may decrease due to induction of its metabolism in the liver.

Absorption of paracetamol may be decreased when used concomitantly with colestyramine, but the decrease in absorption is insignificant if colestyramine is taken one hour later.

Regular use of paracetamol concomitantly with zidovudine may cause neutropenia and increase the risk of liver damage.

Probenecid affects the metabolism of paracetamol. In patients concomitantly using probenecid, the dose of paracetamol should be reduced.

Paracetamol hepatotoxicity is enhanced with prolonged excessive use of ethanol (alcohol).

Paracetamol may affect uric acid test results using a phosphovolframate precipitating reagent.

Pheniramine

The effects of other substances on the CNS (e.g., MAO inhibitors, tricyclic antidepressants, alcohol, anti-Parkinsonian drugs, barbiturates, tranquilizers and narcotics) may be enhanced. Pheniramine may inhibit the effect of anticoagulants.

Phenylephrine

Teraflu® for flu and cold is contraindicated in patients who receive or have received MAO inhibitors during the last 2 weeks. Phenylephrine may potentiate the effects of MAO inhibitors and cause a hypertensive crisis.

Concomitant use of phenylephrine with other sympathomimetic drugs or tricyclic antidepressants (such as amitriptyline) may lead to an increased risk of adverse reactions from the cardiovascular system.

Phenylephrine may decrease the effectiveness of beta-adrenal blockers and other antihypertensive drugs (e.g., debrisochine, guanethidine, reserpine, methyldopa). There may be an increased risk of arterial hypertension and other cardiovascular side effects.

Concomitant use of phenylephrine with digoxin and cardiac glycosides may increase the risk of cardiac rhythm disturbances or myocardial infarction.

Concomitant use of phenylephrine with ergot alkaloids (ergotamine and methysergide) may increase the risk of ergotism

Special Instructions

In order to avoid toxic liver damage the drug should not be combined with the use of alcoholic beverages.

Patients should consult a physician if:

– Bronchial asthma, emphysema or chronic bronchitis are observed;

– symptoms do not resolve within 5 days or are accompanied by severe fever lasting for 3 days, rash or constant headache.

These may be signs of more serious disorders.

Teraflu® for flu and cold contains:

– sucrose 20 g per bag. This should be taken into account in patients with diabetes mellitus. Patients with such rare hereditary problems as fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltase deficiency should not take Teraflu® for flu and cold;

– sunset yellow dye (E110). May cause allergic reactions;

– sodium 28.3 mg per sachet. It should be taken into account in patients on a sodium-restricted diet.

Do not use the drug from damaged bags.

Impact on the ability to drive vehicles and mechanisms

Teraflu® for flu and cold may cause drowsiness, so during treatment it is not recommended to drive vehicles or engage in other activities that require concentration and high speed of psychomotor reactions.

Synopsis

Powder for oral solution (lemon) is white with yellow flecks, loose, granular, without foreign particles, citrus-scented; soft lumps are allowed.

Contraindications

Hypersensitivity to the drug components;
– Severe cardiovascular disease;
– Arterial hypertension;
– Diabetes mellitus;
– Hyperthyroidism;
– Pancreas – portal hypertension;
– diabetes mellitus;
– hyperthyroidism;
– closed-angle glaucoma;
– pheochromocytoma;
– alcoholism;
– Sucrose/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption;
– concurrent or during the preceding 2 weeks taking MAO inhibitors;
– Simultaneous use of tricyclic antidepressants, beta-adrenoblockers, other sympathomimetics;
– pregnancy;
– period of breastfeeding;