Synthomycin, liniment 10% 25 g

The active ingredient of the drug is chloramphenicol – a broad spectrum antibiotic with high antibacterial activity against the causative agent of wound infection and various forms of purulent inflammatory processes.< br> < br> Chloramphenicol is a bacteriostatic antibiotic, disrupts protein synthesis in a microbial cell (possessing high lipophilicity, penetrates through the cell membrane of bacteria and reversibly binds to the subunit < br br> < br> < br> 50S subunit of bacterial ribosomes, as a result, the movement of amino acids to the growing peptide chains is delayed, which leads to disruption of peptide bond formation and protein synthesis). < br> < br> < br> Active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, sulfonamides. < br> < br> < br> Promotes cleansing and healing of burn wounds and trophic ulcers, accelerates epithelialization.< br> < br> < br> Pharmacokinetics: the degree of absorption into the systemic bloodstream after the use of the drug on the skin, wounds or mucous membranes is unknown.< br>

Indications

Composition

How to take, the dosage

The liniment is used externally.

After surgical treatment of wounds and burns synthomycin liniment is applied directly to the wound surface, after which a sterile gauze dressing is applied or synthomycin liniment is applied to the dressing material and then to the wound.

Tabs with liniment loosely fill cavities of purulent wounds after surgical treatment, and gauze turundas with synthomycin liniment are inserted into fistulous passages.

In the treatment of wounds and burns in the 2nd phase – once every 1-3 days depending on the dynamics of wound healing.

Interaction

Barbiturates accelerate biotransformation, reduce concentration and duration of effect.

Decreases the antibacterial effect of penicillins and cephalosporins.

When concomitant use with erythromycin, clindamycin, lincomycin mutual weakening of action is noted.

Disulfiram-like reactions are possible with concomitant use of alcohol.

Special Instructions

Systematic monitoring of peripheral blood counts is necessary during treatment.

There have been no adverse effects on the fetus during pregnancy and breastfeeding.

When applied to large surfaces with concomitant administration of ethanol, disulfiram-like reactions (skin hyperemia, tachycardia, nausea, vomiting, reflex cough, convulsions) may occur.

Contraindications

Side effects