Sympatil, 40 pcs.

The drug Simpatil has a sedative effect, eliminates anxiety and associated vegetative disorders, tachycardia and sleep disorders. Biologically active substances of hawthorn extract – triterpene compounds and flavonoids have antispasmodic effect, selectively expanding heart and brain vessels, reduce excitability of the central nervous system and myocardium.

Esholtia extract has an anxiolytic and sedative effect, shortens the period of falling asleep and improves the quality of sleep in mild forms of dyssomnia. Esholtia alkaloids of the protopine group increase in vitro binding of gamma-aminobutyric acid to the brain receptors sensitive to it.

Magnesium improves regulation of transmembrane metabolism of sodium and potassium ions, is an antagonist of calcium ions, reduces the ability to conduct excitation along neuromuscular synapses, to the contraction of smooth and transverse striated muscles; it also has neurosedative, antispasmodic and anxiolytic effects.

Pharmacokinetics

. Magnesium oxide in the stomach is converted to magnesium chloride, which is absorbed in the small intestine by a passive absorption mechanism, the absorption rate does not exceed 50%. Excretion of magnesium is mainly with urine. The action of the components is difficult for kinetic observations.

Indications

States of emotional tension and stress, accompanied by increased excitability, restlessness, increased irritability, anxiety, fear, increased fatigue, palpitations; sleep disorders (mild).

Pharmacological effect

The drug Sympatil has a sedative effect, eliminates anxiety and associated autonomic disorders, tachycardia and sleep disorders. The biologically active substances of hawthorn extract – triterpene compounds and flavonoids – have an antispasmodic effect, selectively dilating the blood vessels of the heart and brain, reducing the excitability of the central nervous system and myocardium.

Eschscholzia extract has an anxiolytic, sedative effect, reduces the time of falling asleep and improves sleep quality in mild forms of dyssomnia. Eschscholzium alkaloids of the protopine group increase in vitro the connection of gamma-aminobutyric acid with brain receptors sensitive to it.

Magnesium improves the regulation of transmembrane exchange of sodium and potassium ions, is an antagonist of calcium ions, reduces the ability to conduct excitation at neuromuscular synapses, to contract smooth and striated muscles; It also has neurosedative, antispasmodic and anxiolytic effects.

Pharmacokinetics

Magnesium oxide in the stomach is converted to magnesium chloride, which is absorbed in the small intestine using a passive absorption mechanism, the absorption level does not exceed 50%. Excretion of magnesium is mainly carried out in the urine. The action of the components is difficult for kinetic observations.

Special instructions

The patient should be warned about the need to inform the attending physician about the worsening of any of the side effects indicated in the instructions or the occurrence of other side effects not specified in the instructions.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, caution should be exercised when engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions (including driving vehicles, working with moving mechanisms).

Active ingredient

Eschscholzia dry extract, Hawthorn dry extract, Magnesium oxide

Composition

1 film-coated tablet contains:

active ingredients:

eschscholzia dry extract 20.0 mg,

hawthorn extract dry 75.0 mg,

magnesium oxide 124.35 mg,

equivalent to elemental magnesium 75.0 mg;

excipients:

microcrystalline cellulose – 122.0 mg,

sodium carboxymethyl starch – 15.0 mg,

micronized stearic acid – 3.65 mg

Pregnancy

Not recommended for use during pregnancy and breastfeeding

Contraindications

Hypersensitivity to the components of the drug Simpatil,
severe renal failure (creatinine clearance below 30 ml/min),
age up to 18 years.

Side Effects

From the gastrointestinal tract: diarrhea, pain in the epigastric region.

If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

It is not recommended to combine the drug Simpatil with medications containing quinidine, because Renal excretion of quinidine decreases due to alkalinization of urine and an overdose is possible (due to an increase in the concentration of quinidine in the blood plasma).

Overdose

Taking large doses of the drug may lead to urinary retention.

Treatment: rehydration, forced diuresis.

In case of renal failure, hemodialysis or peritoneal dialysis is necessary.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

3 years

Manufacturer

Innotera Chouzy, France