Sulfadimesin, tablets 500 mg, 10 pcs.

A bacteriostatic antimicrobial agent, sulfonamide. Mechanism of action is due to competitive antagonism with para-aminobenzoic acid, inhibition of dihydropteroate synthase, disruption of synthesis of tetrahydrofolic acid required for synthesis of purines and pyrimidines.

Active against Gram-positive and Gram-negative cocci, Escherichia coli, Shigella spp., Klebsiella spp., Vibrio cholerae, Clostridium perfringens, Ba-cillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp., Actinomyces israelii.

Pharmacokinetics

Absorption is fast (mainly in small intestine). Binding with plasma proteins is 75-86%. It penetrates into the tissues (including lungs, cerebrospinal fluid). It is metabolized in liver by acetylation.

Half-life (T1/2) is 7 hours. It is excreted by the kidneys through glomerular filtration. Acetylated metabolites may precipitate when concentrated in urine. Solubility of metabolites is improved with alkaline urine.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: tonsillitis, sinusitis, otitis media, exacerbation of chronic bronchitis, pneumonia, inflammatory diseases of the biliary and urinary tract, shigellosis, erysipelas, wound infection.

Pharmacological effect

Antimicrobial bacteriostatic agent, sulfanilamide. The mechanism of action is due to competitive antagonism with para-aminobenzoic acid, inhibition of dihydropteroate synthase, disruption of the synthesis of tetrahydrofolic acid, necessary for the synthesis of purines and pyrimidines.

Active against gram-positive and gram-negative cocci, Escherichia coli, Shigella spp., Klebsiella spp., Vibrio cholerae, Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp., Actinomyces israelii.

Pharmacokinetics

Absorption is rapid (mainly in the small intestine). Communication with plasma proteins -75-86%. Penetrates well into tissues (including the lungs and cerebrospinal fluid). Metabolized in the liver by acetylation.

The half-life (T1/2) is 7 hours. It is excreted by the kidneys by glomerular filtration. Acetylated metabolites may precipitate when concentrated in urine. The solubility of metabolites improves when the urine is alkalinized.

Special instructions

During treatment, adequate fluid intake should be ensured due to the risk of developing crystalluria.

With long-term use, monitoring of peripheral blood parameters is necessary.

Impact on the ability to drive vehicles and operate machinery

Does not affect driving or engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Sulfadimidine

Composition

1 tablet contains:

active ingredient:

sulfadimidine 500 mg;

excipients:

potato starch,

talc,

stearic acid,

polysorbate 80.

Contraindications

inhibition of bone marrow hematopoiesis,
chronic renal failure,
hyperbilirubinemia in children (risk of developing bilirubin encephalopathy),
congenital deficiency of glucose-6-phosphate dehydrogenase,
porphyria,
azotemia.

Side Effects

nausea,
vomit,
crystalluria,
leukopenia,
agranulocytosis.

Interaction

Reduces the effectiveness of bactericidal and antibiotics that act only on dividing microorganisms (including penicillins and cephalosporins).
Increases (mutually) the hematotoxicity of chloramphenicol, thiamazole.
Benzocaine and procaine reduce antimicrobial activity (during hydrolysis they release para-aminobenzoic acid).
Ascorbic acid and methenamine increase the risk of developing crystalluria.
Non-steroidal anti-inflammatory drugs, hypoglycemic drugs (sulfonylurea derivatives), phenytoin and coumarin anticoagulants increase the severity of the side effects of the drug (leukopenia, agranulocytosis).
Antacids reduce intestinal absorption.
For toxoplasmosis, combination with pyrimethamine is possible.
Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.

Overdose

There are no data on overdose.

Storage conditions

In a place protected from light at a temperature not exceeding 20 °C.

Shelf life

2 years.

Manufacturer

Irbitsky Chemical Plant, Russia