Sparex, 135 mg 60 pcs

Pharmacodynamics

Myotropic antispasmodic, has direct action on the smooth muscles of the gastrointestinal tract without affecting normal intestinal peristalsis.

The exact mechanism of action is unknown, but multiple mechanisms, such as decreased ion channel permeability, norepinephrine reuptake blockade, local anesthetic action, and altered water absorption may cause local gastrointestinal effects of mebeverine.

By these mechanisms, mebeverine exhibits an antispasmodic effect, normalizing intestinal peristalsis without causing permanent relaxation of gastrointestinal smooth muscle cells (“hypotonia”). There are no systemic side effects, including anticholinergic.

Pharmacokinetics

Intake

Meberine is quickly and completely absorbed after oral administration.

Distribution

There is no significant accumulation with repeated doses of the drug.

Metabolism

Meberine hydrochloride is primarily metabolized by esterases, which first break down the ester into veric acid and meberine alcohol. The main metabolite circulating in plasma is demethylated carboxylic acid.

The equilibrium elimination half-life of demethylated carboxylic acid is approximately 2.45 h. With repeated doses, the maximum concentration of demethylated carboxylic acid in the blood (Cmax) is 1670 ng/ml, the time of reaching the maximum concentration of demethylated carboxylic acid in the blood (Tmax) is 1 hour.

Elimation

Meberine as such is not excreted from the body, but is completely metabolized; its metabolites are almost completely excreted from the body. Veratroic acid is excreted by the kidneys. The alcohol of mebeverine is also excreted by the kidneys, partly as carboxylic acid and partly as demethylated carboxylic acid.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Consult your doctor before taking Sparex® if:

Contraindications

Side effects

Overdose

Pregnancy use

Similarities