Sodium sulfacyl, eye drops 20% 5 ml

Pharmacotherapeutic group

Antimicrobial agents. Sulfonamides.

ATC code S01AB04

Pharmacological properties

Pharmacokinetics

. When applied topically, the Cmax of sulfonamides in the cornea (about 3 mg/mL), anterior chamber moisture (about 0.5 mg/mL), and iris (about 0.1 mg/mL) is reached within the first 30 minutes after application. Some amount (less than 0.5 mg/ml) persists in the eyeball tissues for 3-4 hours. Penetration of sulfonamides increases if the corneal epithelium is damaged.

Pharmacodynamics

Sulfacyl sodium is a sulfonamide antimicrobial agent of broad spectrum action. It has bacteriostatic action. Mechanism of action is related to competitive antagonism with PABA and inhibition of dihydropteroatsintase which leads to disruption of tetrahydrofolic acid synthesis, required for purine and pyrimidine synthesis.

Active against Gram-positive and Gram-negative cocci, Escherichia coli, Shigella spp., Vibrio cholerae, Clostridium perfringens, Bacillus antracis, Corynebacterium diphteriae, Yersinia pestis, Chlamydia spp., Actinomyces israelii, Toxoplasma gondii.

Indications

– conjunctivitis

– blepharitis

– purulent corneal ulcer

– prevention and treatment of blennorrhea in infants

– gonorrheal and chlamydial eye disease in adults

Active ingredient

Sulfacetamide

Composition

1 ml of the solution contains:

The active substance: sodium sulfacetamide (sulfacyl sodium) – 200 mg.

Auxiliary substances: sodium thiosulfate – 1.0 mg, hydrochloric acid (hydrochloric acid) – to pH 7.5 – 8.7, purified water – to 1 ml.

How to take, the dosage

For the treatment of conjunctivitis in children and adults it is instilled into the conjunctival sac 1-2 drops every hour, in the next 3-4 days – 5-6 times a day.

For treatment of blepharitis in children and adults the instillation frequency is 6-8 times during the first days and decreases to 3-4 times a day as the condition improves. The duration of treatment is 3-5 days.

For treatment of purulent corneal ulcer as part of complex therapy in the form of instillations 5-6 times a day for 5-7 days.

To prevent blennorrhea in newborns 2 drops drop drops are put into each conjunctival sac immediately after birth and 2 drops every 2 hours during the day. For treatment of blennorrhea in newborns – 2 drops in each conjunctival sac every 1 to 2 hours during the first day, then every 3 hours thereafter. The duration of treatment is 2 weeks.

In the treatment of gonorrheal and chlamydial eye diseases in adults in the complex therapy 1-2 drops 5-6 times a day for 4-6 weeks. In case of positive dynamics on the background of ongoing treatment the number of instillations of drops is reduced in each subsequent week.

Interaction

Co-administration with procaine and tetracaine reduces the bacteriostatic effect of sulfacetamide. Sulfacetamide is observed to be incompatible when coadministered with silver salts. Concomitant administration with chloramphenicol increases the risk of side effects of the latter.

Directions for use

Open the tube-dropper by turning the cap around its axis; drip the solution by pressing the body of the tube-dropper; close the tube-dropper with the cap to the stop.

Special Instructions

Patients with hypersensitivity to furosemide, thiazide diuretics, sulfonylurea derivatives or carbohydrate inhibitors may exhibit hypersensitivity to sulfacetamide.

Pregnancy and lactation

There is no sufficient experience on the use of the drug during pregnancy and lactation. It is possible to use sulfacetamide for treatment of pregnant and nursing women by prescription of the attending physician if the expected therapeutic effect for the mother exceeds the risk of possible side effects for the fetus and the child.

Particulars of the effect of the drug on the ability to drive and operate potentially dangerous machinery

If the patient’s visual acuity is temporarily reduced after the use of the drug, until its recovery it is not recommended to perform potentially dangerous activities requiring particular attention and quick reactions (driving a car and other vehicles, operation of traffic controllers, etc.).

Contraindications

Individual hypersensitivity to the drug components.

Side effects

There may be local tissue irritation:

– transient burning

– transient blurring of vision after injection, lacrimation

– redness, tears

– itching in the eyes

– local allergic reactions

Similarities

Sulfacyl sodium eye drops, Sulfacyl sodium-SOLofarm, Sulfacyl sodium Renewal