Sodium chloride, 0.90% 250 ml

Pharmacotherapeutic group

Solvent

Pharmacological action

Sodium and chlorine ions are the most important inorganic components of extracellular fluid, maintaining the appropriate osmotic pressure of blood plasma and extracellular fluid. Isotonic solution replenishes fluid deficits in the body during dehydration. Hypertonic sodium chloride solution when administered intravenously provides correction of osmotic pressure of extracellular fluid and blood plasma. When used topically in ophthalmology sodium chloride has an anti-edema effect.

Indications

Isotonic solution: dehydration of various origins. To maintain blood plasma volume during and after surgery. As a solvent for various drugs.

Hypertonic solution: disturbances of water-electrolyte metabolism – deficiency of sodium and chlorine ions; hypoosmolar dehydration of various origins (due to prolonged vomiting, diarrhea, burns; gastric fistula, pulmonary hemorrhage, intestinal bleeding).

Pharmacological effect

Pharmacotherapeutic group

Solvent

Pharmacological action

Sodium and chlorine ions are the most important inorganic components of the extracellular fluid, maintaining the appropriate osmotic pressure of the blood plasma and extracellular fluid. An isotonic solution replenishes fluid deficiency in the body during dehydration. Hypertonic sodium chloride solution, when administered intravenously, provides correction of the osmotic pressure of extracellular fluid and blood plasma. When applied topically in ophthalmology, sodium chloride has an anti-edematous effect.

Special instructions

Large volumes of sodium chloride should be used with caution in patients with impaired renal excretory function or hypokalemia. The introduction of large quantities of solution can lead to chloride acidosis, overhydration, and increased excretion of potassium from the body.

Hypertonic solution is not used subcutaneously or intramuscularly.

With long-term use, monitoring of plasma electrolyte concentrations and daily diuresis is necessary.

The temperature of the infusion solution should be 38°C.

Active ingredient

Sodium chloride

Composition

1000 ml of solution contains:

Active substance:

Sodium chloride – 9.0 g

Excipient:

Water for injection – up to 1000 ml

Electrolyte concentration:

Sodium – 154 mmol/l

Chloride – 154 mmol/l

Physico-chemical characteristics:
Theoretical osmolarity 308 mOsm/l
pH 4.5 – 7.0

Pregnancy

During pregnancy and breastfeeding, use is possible according to indications in cases where the expected benefit to the mother outweighs the potential risk to the fetus or infant.

Contraindications

Hypersensitivity to sodium chloride; hypernatremia, states of hyperhydration, threat of pulmonary and cerebral edema.

Side Effects

Possible: nausea, vomiting, diarrhea, stomach cramps, thirst, lacrimation, sweating, fever, tachycardia, arterial hypertension, impaired renal function, edema, shortness of breath, headache, dizziness, anxiety, weakness, twitching and muscle hypertonicity.

For external and local use, no adverse reactions have been established to date.

Interaction

NSAIDs, androgens, estrogens, anabolic hormones, corticotropin, mineralocorticoids, vasodilators, ganglion blockers lead to increased Na+ retention.

Storage conditions

At a temperature not exceeding 25 °C.

Shelf life

3 years

Manufacturer

Gematek, Russia