Skinoclear, 15% gel 30 g

Causes moderate cytostatic effect (due to inhibition of cell proteins synthesis) manifested in normalization of keratinization processes in the wall of sebaceous follicles; it has antimicrobial action (first of all against Propionibacterium acnes and Staphylococcus epidermidis) both on the skin surface and in sebaceous glands as well as anti-inflammatory action (reducing neutrophil granulocytes metabolism and production of free radical oxygen forms – important factors in maintaining the inflammatory process).

Long-term use of the drug does not form resistance of microorganisms.

Aselaic acid dose-dependently inhibits the growth and viability of abnormal melanocytes. The therapeutic effect in hyperpigmentation (melasma) is due to inhibition of DNA synthesis and/or suppression of cellular respiration of abnormal melanocytes.

Pharmacokinetics:

Assimilation

After application to the skin, azelaic acid penetrates the epidermis and dermis. After 1 g of azelaic acid (which corresponds to 5 g of gel) is applied to the skin, about 36% of the dose is absorbed into the systemic bloodstream.

Excretion

Part of the absorbed azelaic acid is excreted unchanged by the kidneys, and part as dicarboxylic acid (C5 C7) formed from azelaic acid by beta-oxidation.

Indications

• One acne (acne vulgaris);
• Hyperpigmentation such as melasma.

Active ingredient

Azelaic acid

Composition

Per 100 g of gel:

Active ingredient: azelaic acid – 15.0 g;

Auxiliary substances: carbomer 980 – 1.0 g, benzoic acid – 0.1 g, edetate dihydrate – 0.1 g, ceramides LS – 0.1 g, isopropyl myristate – 1.0 g, polysorbate-20 – 1.5 g, propylene glycol – 12.0 g, sodium hydroxide – 0.2 g, water – to 100.0 g.

How to take, the dosage

Externally. The maximum duration of therapy depends on the individual disease pattern and the severity of symptoms and is determined by the attending physician.

Interaction

Interaction of the drug with other drugs is not yet known.

Contraindications

• High sensitivity to azelaic acid and other ingredients of the drug
• Children under 12 years

.

Side effects

Adverse reactions are presented according to the frequency of development: very common (≥ 1/10); common (≥ 1/100 to <1/10); infrequent (≥ 1/1000 to <1/100) rare (≥ 1/10000 to <1/1000) very rare (<1/10 000) unknown (cannot be estimated based on available data).

Skin and subcutaneous fat disorders:

Infrequent: seborrhea acne skin depigmentation;

Very common: Itching burning erythema at the site of application;

Often: flaking dry skin irritation;

Rarely: cheilitis.

General disorders and disorders together with administration:

Infrequent: paresthesias dermatitis discomfort edema at the application site;

Rarely: vesicular rash eczema sensation of heat rash at the application site;

Often: pain at the application site.

Immune system disorders:

Rarely: allergic reaction worsening the course of bronchial asthma.

In general, local reactions on the skin resolve on their own during treatment.

If any of the side effects listed in the instructions worsen, or if any other side effects not listed in the instructions are noted, you should tell your doctor immediately.

Overdose

No cases of overdose have been described at this time.

Pregnancy use

In pregnancy and during breastfeeding, the drug should be used only if the expected benefits to the mother outweigh the possible risks to the fetus and the baby.

Application of the gel to the mammary gland area before breastfeeding should be avoided.

Similarities

Skinoren, Azelik, Azix-derm