Sinuforte, lyophilizate 50 mg + and nozzle

Sinuforte is a drug of plant origin for the treatment of inflammatory diseases of the paranasal sinuses (PNS) and the nasal cavity.

Pharmacodynamics

The drug is of plant origin for the treatment of inflammatory diseases of the paranasal sinuses (PNS) and the nasal cavity. The drug affects the sensitive trigeminal nerve receptors in the middle nasal passage and causes reflexive secretion in the mucous membrane of the nasal cavity and PNS. Stimulated hypersecretion is accompanied by changes in rheological properties of the secretion and normalization of its viscosity. Reflex hypersecretion in combination with antiedematous action of the drug leads to evacuation of the secretion from sinuses into nasopharynx and provides physiological drainage of all sinuses simultaneously.

The drug promotes restoration of mucociliary transport in the nasal cavity and PNS by strengthening the presence of the liquid part of the secretion in the surface layer of mucus. Sinuforte increases microcirculation in the nasal mucosa and PNS. This is due to the fact that parasympathetic stimulation, which activates secretion, also causes vasodilation of the vessels supplying the glands.

The increased reflex secretion in the form of serous-mucous secretions is detectable in a few minutes and can last from 30 to 120 minutes, depending on individual body characteristics.

Pharmacokinetics

The action of the drug Sinuforte is due to the combined effects of the components of cyclamen, of which the most studied are the triterpene saponins. Kinetic studies are not possible since the complex of components cannot be traced by markers or bioassays. For the same reason it is not possible to detect the metabolites of the drug.

Indications

complex therapy of rhinosinusitis accompanied by exudative otitis media;
complex therapy of acute and chronic sinusitis: chronic runny nose, sinusitis, frontal sinusitis, ethmoiditis and sphenoiditis (in the case of purulent sinusitis, occurring with symptoms of generalization of infection and/or orbital complications, Sinuforte should be used only in combination with antibiotics). In case of uncomplicated course of the disease, it is possible to use the drug as a monotherapy under the supervision of a physician;
the period of early postoperative rehabilitation after endoscopic surgical interventions on the paranasal sinuses.

Pharmacological effect

Sinuforte is a herbal preparation for the treatment of inflammatory diseases of the paranasal sinuses (SNS) and the nasal cavity.

Pharmacodynamics

A herbal preparation for the treatment of inflammatory diseases of the paranasal sinuses (SNS) and nasal cavity. The drug acts on the sensitive receptors of the trigeminal nerve in the area of ​​the middle nasal meatus and causes reflex secretion in the mucous membrane of the nasal cavity and SNP. Stimulated hypersecretion is accompanied by a change in the rheological properties of the secretion and normalization of its viscosity. Reflex hypersecretion in combination with the anti-edematous effect of the drug leads to the evacuation of secretions from the sinuses into the nasopharynx and provides physiological drainage of all sinuses simultaneously.

The drug helps restore mucociliary transport in the nasal cavity and SNP by enhancing the presence of the liquid part of the secretion in the surface layer of mucus. Sinuforte increases blood microcirculation in the nasal mucosa and SNP. This is because parasympathetic stimulation, which activates secretion, also causes vasodilation of the vessels supplying the glands.

Increased reflex secretion in the form of serous-mucosal discharge is detected after a few minutes and can last from 30 to 120 minutes, depending on the individual characteristics of the body.

Pharmacokinetics

The effect of Sinuforte is due to the combined effects of cyclamen components, the most studied of which are triterpene saponins. Kinetic studies are not possible because the complex of components cannot be traced using markers or bioassays. For the same reason, it is impossible to detect drug metabolites.

Special instructions

During the period of postoperative rehabilitation after endoscopic interventions, Sinuforte is used on the second day to cleanse (sanitize) the paranasal sinuses and nasal cavity and reduce swelling of the mucous membrane.

When using, avoid contact of Sinuforte with the eyes due to the irritant effect of the drug on the mucous membrane of the eye and the possible development of acute conjunctivitis.

It is recommended to hold your breath during administration of the drug.

Direct spraying of the drug should be carried out with one click with the head in a vertical position.

Before use, it is recommended to consult an otolaryngologist.

Active ingredient

Lyophilisate of juice and extract of fresh European cyclamen tubers

Composition

1 bottle of lyophilisate for preparing a solution for intranasal administration contains:

Active ingredient:

lyophilisate of juice and extract of fresh European cyclamen tubers 50 mg;

Solvent:

water for injection – 5 ml

Pregnancy

Contraindicated during pregnancy. Breastfeeding should be stopped during treatment.

Contraindicated in children under 5 years of age (use in children under 5 years of age has not been studied).

Contraindications

Hypersensitivity;
polypous rhinosinusitis;
paranasal sinus cysts;
allergic rhinosinusopathy;
allergic reactions (delayed and immediate type);
arterial hypertension II–III degree.

Side Effects

There may be a feeling of mild or moderate burning in the nasal cavity, salivation and/or lacrimation in response to irritation of the sensitive receptors of the trigeminal nerve.

In some cases, redness of the face, a short headache in the frontal region, or pale pink discharge from the nose may appear as a result of capillary diapedesis. The above short-term physiological reactions confirm the reflex mechanism of action of the drug and do not require cessation of treatment.

Allergic reactions are possible (including skin rash, shortness of breath, etc.). In these cases, it is recommended to stop taking the drug and consult a specialist.

Interaction

It is necessary to refrain from prior administration, as well as simultaneous use of local anesthetics and/or local decongestants due to a possible violation of the mechanism of action of the drug Sinuforte.

If necessary, a combination of Sinuforte with antibacterial drugs is possible.

Interaction with other drugs has not yet been studied.

Overdose

Currently, no cases of overdose of Sinuforte have been reported. Exceeding a single dose does not lead to an increase in the therapeutic effect and can cause a strong burning sensation and pain in the nasopharynx.

If symptoms of overdose appear, it is necessary to carry out symptomatic therapy: rinse the nasal cavity, gargle with warm water and use antihistamines.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 °C

Shelf life

5 years

Manufacturer

Pharma Mediterranna S.L., Spain