Sinaflan, 0.025% ointment 15 g

Pharmacodynamics

Glucocorticosteroid (GCS) for external use; inhibits the release of inflammatory mediators. When applied to the skin it prevents marginal accumulation of neutrophils, which leads to a decrease in inflammatory exudate and cytokine production, inhibition of macrophage migration, reduction of infiltration and granulation processes. It has anti-inflammatory and antiallergic effect.

Pharmacokinetics

After absorption from the skin surface is bound with plasma proteins and metabolized in the liver with the formation of inactive metabolites. It is excreted mainly by the kidneys.

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Indications

Eczema,
atonic dermatitis,
simple chronic lichen (limited neuro­dermatitis),
toxicermy,
simple allergic dermatitis,
seborrheic dermatitis, k
burning itching,
hives,
pruritus,
intertrigo,
exudative erythema multiforme,
psoriasis (exudative form),
lichen planus,
discoid lupus erythematosus,
hand dyshidrosis,
otitis externa, 1st degree burns,
insect bites.

Pharmacological effect

Pharmacodynamics

Glucocorticosteroid (GCS) for external use; inhibits the release of inflammatory mediators. When exposed to the skin, the accumulation of neutrophils is prevented, which leads to a decrease in inflammatory exudate and cytokine production; inhibition of macrophage migration, reduction of infiltration and granulation processes. Has anti-inflammatory and anti-allergic effects.

Pharmacokinetics

After absorption from the surface of the skin, it binds to plasma proteins and is metabolized in the liver to form inactive metabolites. Excreted mainly by the kidneys.

Special instructions

Use only in short courses on small areas of skin.

The drug should not be applied to the face. Avoid getting the drug into your eyes. The duration of administration in children should not exceed 5 days. It is recommended to wear loose clothing during treatment.

In patients with acne vulgaris or rosacea, the disease may worsen during treatment.

To prevent local infectious complications, it is recommended to prescribe in combination with antimicrobial agents.

Active ingredient

Fluocinolone acetonide

Composition

100 g of ointment contains:

active substance:

fluocinolone acetonide – 0.025g

excipients: propylene glycol, petroleum jelly (medicinal petroleum jelly), anhydrous lanolin, ceresin.

Contraindications

Hypersensitivity,
skin manifestations of syphilis,
lupus,
diaper rash,
rosacea,
extensive psoriatic plaques,
anogenital itching;
skin infections caused by bacteria, viruses, fungi – pyoderma, chickenpox, herpes, actinomycosis, blastomycosis, sporotrichosis, trophic leg ulcers associated with varicose veins, erosive and ulcerative lesions of the gastrointestinal tract (GIT), wounds at application sites, skin cancer, nevus, atheroma, melanoma, hemangioma.
xanthoma,
sarcoma,
pregnancy,
lactation period,
children’s age (up to 2 years)
With caution: In girls during puberty.

Side Effects

Burning, itching, steroid acne, stretch marks, dry skin, folliculitis.

With long-term use – skin atrophy, local hirsutism, hypertrichosis, telangiectasia, purpura, skin pigmentation disorders, alopecia, especially in women, secondary immunodeficiency (exacerbation of chronic infectious diseases, generalization of the infectious process, development of opportunistic infections), when applied to large surfaces, systemic manifestations are possible (gastritis, “steroid” stomach ulcer, adrenal insufficiency, Itsenko-Cushing syndrome, “steroid” diabetes mellitus, slowdown of reparative processes).

Interaction

Compatible with antimicrobial agents.

Reduces the activity of antihypertensive, diuretic, antiarrhythmic drugs, potassium supplements. Diuretics (except potassium-sparing drugs) increase the risk of hypokalemia.

Overdose

Symptoms: itching and burning of the skin at the site of application of the drug, hyperglycemia, glucosuria, Itsenko-Cushing syndrome

Treatment: symptomatic with gradual withdrawal of the drug.

Storage conditions

In a dry place, at a temperature of 12–15 °C

Shelf life

5 years

Manufacturer

Biokhimik JSC, Russia