Semax, drops 0.1% 3 ml

Pharmacotherapeutic group. Notropic drug.

ATX code – [N06BX]

Pharmacological properties. Semax drops 0.1% is an original synthetic peptide preparation which is an analog of the adrenocorticotropic hormone fragment (ACTH4-10) (methionyl-glutamyl-histidyl-phenylalanyl-prolylglycyl-proline) and is absolutely devoid of hormonal activity. All amino acids are L-form.

Pharmacodynamics.

Semax nasal drops 0.1% has an original mechanism of neurospecific action on the central nervous system (CNS). Semax nasal drops 0.1% is a synthetic analog of corticotropin, which has nootropic properties and is completely devoid of hormonal activity. The drug affects processes related to memory formation and learning. Semax nasal drops 0.1% intensifies attention during learning and information analysis, improves consolidation of memory trace in patients after neurosurgical operations, craniocerebral injury, patients suffering from cerebrovascular diseases, including cerebrovascular encephalopathy; it improves adaptation of the body to hypoxia, cerebral ischemia, narcosis and other damaging influences. The drug is practically non-toxic when administered once and for a long time. It does not exhibit allergic, embryotoxic, teratogenic and mutagenic properties. It has no local irritant effect.

Pharmacokinetics.

It is absorbed from the nasal mucosa with absorption up to 60-70% of the active substance. Semax 0.1% nasal drops are rapidly distributed to all organs and tissues, penetrating through the blood-brain barrier. Once in the blood, Se-max nasal drops 0.1% undergoes rapid biotransformation and is eliminated from the body with the urine.

Indications

Intellectual-mnestic disorders in vascular lesions of the brain, conditions after traumatic brain injury, neurosurgical operations and anesthesia, dyscircular encephalopathy, transient cerebrovascular accidents (TIA), as well as neurotic disorders of various origins, including after ionizing radiation, the recovery period after a stroke. To increase the adaptive capabilities of the human body in extreme situations, to prevent mental fatigue during monotonous operator activity during the most intense periods of work under stressful conditions.

In ophthalmology, Semax is used for optic nerve atrophy, neuritis of inflammatory, toxic-allergic etiology.

In pediatrics: as a nootropic agent in children over the age of 7 years in the treatment of minimal brain dysfunction (including ADHD – attention deficit hyperactivity disorder).

Pharmacological effect

Pharmacotherapeutic group. Nootropic drug.

ATX code – [N06BX]

Pharmacological properties. Semax nasal drops 0.1% is an original synthetic peptide drug, which is an analogue of a fragment of adrenocorticotropic hormone (ACTH4-10) (methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline), completely devoid of hormonal activity. All amino acids are L-form.

Pharmacodynamics. Semax nasal drops 0.1% has an original mechanism of neurospecific action on the central nervous system (CNS). Semax nasal drops 0.1% is a synthetic analogue of corticotropin, which has nootropic properties and is completely devoid of hormonal activity. The drug affects processes associated with memory formation and learning. Semax nasal drops 0.1% enhances attention when learning and analyzing information, improves the consolidation of the memory trace in patients after neurosurgical interventions, traumatic brain injury, suffering from cerebrovascular diseases, including dyscirculatory encephalopathy; improves the body’s adaptation to hypoxia, cerebral ischemia, anesthesia and other damaging influences. The drug is practically non-toxic with single and long-term administration. Does not exhibit allergic, embryotoxic, teratogenic and mutagenic properties. Does not have a local irritant effect.

Pharmacokinetics. Absorbed from the mucous membrane of the nasal cavity, up to 60-70% is absorbed in terms of the active substance. Semax nasal drops 0.1% are quickly distributed throughout all organs and tissues and penetrate the blood-brain barrier. When Semax nasal drops 0.1% enter the bloodstream, they undergo rapid biotransformation and are excreted from the body in the urine.

Active ingredient

Methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline

Composition

Semax in terms of 100% substance – 1 g, methyl parahydroxybenzoate (Nipagin) – 1 g, purified water up to 1 liter.

Contraindications

Hypersensitivity to the components of the drug. Children under 7 years old. In ophthalmological and neurosurgical practice, children under 18 years of age. Pregnancy, lactation, acute mental conditions, disorders accompanied by anxiety, history of seizures.
Use in children under 18 years of age in ophthalmological and neurosurgical practice is contraindicated. No clinical studies have been conducted.
Use during pregnancy and lactation. Contraindicated. No clinical studies have been conducted.

Side Effects

With prolonged use, mild irritation of the nasal mucosa is possible.

Interaction

Pharmaceutical. Based on the chemical structure of the drug, the presence of chemically incompatible combinations is not expected: the drug is quickly destroyed and does not enter the gastrointestinal tract.

Pharmacokinetic. Considering the chemical structure of the drug (heptapeptide is a synthetic analogue of adrenocorticotropic hormone, completely devoid of hormonal activity), the rate of absorption and rate of entry into the blood, as well as the intranasal route of administration, the influence of other drugs on the pharmacokinetic parameters of Semax nasal drops 0.1% is not expected. Considering the method of administration of Semax nasal drops 0.1% (intranasal), it is undesirable to administer agents that have a local vasoconstrictor effect when administered intranasally.

Storage conditions

Store in a place protected from light at a temperature not exceeding 10°C.
Do not freeze. Store the opened bottle at a temperature not exceeding 25°C for no more than 30 days. Keep out of the reach of children.

Shelf life

2 years. Do not consume after the expiration date indicated on the package.

Manufacturer

Peptogen, Russia